Raman spectroscopic characterization of drying-induced structural changes in a therapeutic antibody: correlating structural changes with long-term stability

We characterized the secondary structure of a therapeutic recombinant humanized monoclonal antibody (rhuMAb), formulated with different concentrations of sucrose, trehalose, and histidine and in solution, lyophilized, and spray-dried states. Quantitative secondary structure estimates were obtained u...

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Bibliographic Details

Published in:	Journal of pharmaceutical sciences Vol. 93; no. 4; p. 1005
Main Authors:	Sane, Samir U, Wong, Rita, Hsu, Chung C
Format:	Journal Article
Language:	English
Published:	United States 01-04-2004
Subjects:	Antibodies, Monoclonal - chemistry Chemistry, Pharmaceutical Chromatography, Gel Drug Stability Freeze Drying Histidine - chemistry Humans Pharmaceutical Solutions Protein Conformation Protein Structure, Secondary Spectrum Analysis, Raman Sucrose Trehalose - chemistry
Online Access:	Get more information
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