In vivo inefficiency of pentoxifylline and interferon-alpha on hepatic fibrosis in biliary-obstructed rats: Assessment by tissue collagen content and prolidase activity

Background and Aim: To evaluate the possible antifibrotic effects of two drugs, pentoxifylline (PTX) and interferon (IFN)‐α as well as their combination, on a bile‐duct‐ligated rat hepatic fibrosis model. Methods: Bile ducts of 34 female Wistar rats were ligated, and 24 bile ducts were sham operated...

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Bibliographic Details
Published in:	Journal of gastroenterology and hepatology Vol. 18; no. 4; pp. 437 - 444
Main Authors:	TARÇIN, ORHAN, AVŞAR, KADİR, DEMİrtüRK, LEVENT, GÜLTEPE, MUSTAFA, OKTAR, BERNA K, ÖZDOğAN, OSMAN C, TARÇIN, ÖZLEM, BALOğLU, HÜSEYİN, GÜRBüZ, AHMET K
Format:	Journal Article
Language:	English
Published:	Melbourne, Australia Blackwell Science Pty 01-04-2003 Blackwell Science
Subjects:	Animals antifibrotic bile duct ligation Biological and medical sciences Cholestasis - drug therapy Cholestasis - enzymology Cholestasis - pathology Collagen - analysis combination combination, hepatic fibrosis Dipeptidases - blood Disease Models, Animal Drug Therapy, Combination Female Gastroenterology. Liver. Pancreas. Abdomen hepatic fibrosis Immunologic Factors - administration & dosage Immunologic Factors - therapeutic use interferon-alpha Interferon-alpha - administration & dosage Interferon-alpha - therapeutic use Liver Cirrhosis - drug therapy Liver Cirrhosis - enzymology Liver Cirrhosis - pathology Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology pentoxifylline Pentoxifylline - administration & dosage Pentoxifylline - therapeutic use Platelet Aggregation Inhibitors - administration & dosage Platelet Aggregation Inhibitors - therapeutic use prolidase rat Rats Rats, Wistar Treatment Failure Biliary tract Vasodilator agent Rat Alpha interferon Liver Hepatic disease Biliary tract disease Obstruction bile duct ligation Immunotherapy Complication Xanthine derivatives combination Drug combination Cytokine Rodentia Biological activity Pentoxifylline Vertebrata Chemotherapy Experimental disease Mammalia prolidase Animal Fibrosis Digestive diseases interferon-alpha hepatic fibrosis antifibrotic
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