THE EFFECTS OF LOSARTAN AND IMMOBILIZATION STRESS ON HEART RATE VARIABILITY AND PLASMA CORTICOSTERONE LEVELS IN RATS

In this study, the effects of losartan, an angiotensin II receptor antagonist, on heart rate variability and the changes of plasma corticosterone levels caused by immobilization stress were investigated. Losartan (3 mg/kg, p.o.) significantly prevented increases in plasma corticosterone levels in bo...

Full description

Saved in:

Bibliographic Details
Published in:	International journal of neuroscience Vol. 114; no. 3; pp. 365 - 379
Main Authors:	ÜRESIN, ALI YAGIZ, TONYALI, HÜSEYIN, KARAMÜRSEL, SACIT
Format:	Journal Article
Language:	English
Published:	London Informa UK Ltd 01-03-2004 Taylor & Francis
Subjects:	Affectivity. Emotion Analysis of Variance Animals Antihypertensive Agents - pharmacology Biological and medical sciences Corticosterone - blood Electroencephalography - methods Fundamental and applied biological sciences. Psychology Heart Rate - drug effects Immobilization Losartan - pharmacology Male Personality. Affectivity Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Rats Rats, Wistar Stress, Psychological - blood Stress, Psychological - physiopathology Time Factors Affect affectivity Tetrazole derivatives Rat Corticosterone Variability Rodentia Non peptide compound Emotion emotionality AT1 angiotensin receptor Sympathetic nervous system Glucocorticoid Heart rate Vertebrata Restraint stress Mammalia Biphenyl derivatives Autonomic nervous system Animal Losartan Adrenal hormone Antihypertensive agent Angiotensin antagonist Antagonist Angiotensin II
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	In this study, the effects of losartan, an angiotensin II receptor antagonist, on heart rate variability and the changes of plasma corticosterone levels caused by immobilization stress were investigated. Losartan (3 mg/kg, p.o.) significantly prevented increases in plasma corticosterone levels in both losartan+acute stress and losartan+chronic stress groups. But, losartan did not prevent the diminution of the power of heart rate variability caused by stress. Our results supported the idea that the renin-angiotensin system is also involved in the stress--induced cardiovascular response, besides the autonomic nervous system. But, the effects of losartan on heart rate variability remained controversial
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0020-7454 1563-5279 1543-5245
DOI:	10.1080/00207450490270587