Human mtDNA Haplogroups Associated with High or Reduced Spermatozoa Motility

A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenoty...

Full description

Saved in:

Bibliographic Details
Published in:	American journal of human genetics Vol. 67; no. 3; pp. 682 - 696
Main Authors:	Ruiz-Pesini, Eduardo, Lapeña, Ana-Cristina, Díez-Sánchez, Carmen, Pérez-Martos, Acisclo, Montoya, Julio, Alvarez, Enrique, Díaz, Miguel, Urriés, Antonio, Montoro, Luis, López-Pérez, Manuel J., Enríquez, José A.
Format:	Journal Article
Language:	English
Published:	Chicago, IL Elsevier Inc 01-09-2000 University of Chicago Press The American Society of Human Genetics
Subjects:	Base Sequence Biological and medical sciences Birth control DNA, Mitochondrial - genetics European Continental Ancestry Group - genetics Extrachromosomal Inheritance - genetics Female Gene Frequency - genetics Gynecology. Andrology. Obstetrics Haplotypes - genetics Heterozygote Humans Infertility, Male - genetics Infertility, Male - pathology Male Medical sciences Mitochondria - enzymology Mitochondria - genetics Mitochondria - metabolism Mutation - genetics Oxidative Phosphorylation Phenotype Polymorphism, Genetic - genetics RNA, Transfer - genetics Sperm Motility - genetics Sperm Tail - physiology Spermatozoa - enzymology Spermatozoa - metabolism Spermatozoa - pathology Spermatozoa - physiology Sterility. Assisted procreation Human Spermatozoa Pathogenesis Mobility Exploration Mitochondrial DNA Genetic determinism Semen disorders Oligospermia Male sterility Mutation Asthenospermia Caucasoid Male genital diseases Haplotype
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Abstract	A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenotypic consequence, these mutations could be fixed as stable mtDNA variants, because mtDNA is maternally inherited. To test this possibility, we have performed an extensive analysis of the distribution of mtDNA haplogroups in white men having fertility problems. We have found that asthenozoospermia, but not oligozoospermia, is associated with mtDNA haplogroups in whites. Thus, haplogroups H and T are significantly more abundant in nonasthenozoospermic and asthenozoospermic populations, respectively, and show significant differences in their OXPHOS performance.
AbstractList	A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA genetic alterations can also be responsible for sperm dysfunction. In addition, it was suggested that if sperm dysfunction is the main phenotypic consequence, these mutations could be fixed as stable mtDNA variants, because mtDNA is maternally inherited. To test this possibility, we have performed an extensive analysis of the distribution of mtDNA haplogroups in white men having fertility problems. We have found that asthenozoospermia, but not oligozoospermia, is associated with mtDNA haplogroups in whites. Thus, haplogroups H and T are significantly more abundant in nonasthenozoospermic and asthenozoospermic populations, respectively, and show significant differences in their OXPHOS performance.
Author	Montoya, Julio López-Pérez, Manuel J. Ruiz-Pesini, Eduardo Díaz, Miguel Montoro, Luis Lapeña, Ana-Cristina Alvarez, Enrique Urriés, Antonio Díez-Sánchez, Carmen Pérez-Martos, Acisclo Enríquez, José A.
AuthorAffiliation	1 Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 2 Unidad de Andrología. Hospital 12 de Octubre de Madrid, 3 Clínica Ginecológica de Zaragoza, and 4 Nueva Clínica Quirón de Zaragoza, Zaragoza, Spain; and 5 Laboratorio de Reproducción Humana, Hospital Principe de Asturias, Alcalá de Henares, Madrid
AuthorAffiliation_xml	– name: 1 Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, 2 Unidad de Andrología. Hospital 12 de Octubre de Madrid, 3 Clínica Ginecológica de Zaragoza, and 4 Nueva Clínica Quirón de Zaragoza, Zaragoza, Spain; and 5 Laboratorio de Reproducción Humana, Hospital Principe de Asturias, Alcalá de Henares, Madrid
Author_xml	– sequence: 1 givenname: Eduardo surname: Ruiz-Pesini fullname: Ruiz-Pesini, Eduardo organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 2 givenname: Ana-Cristina surname: Lapeña fullname: Lapeña, Ana-Cristina organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 3 givenname: Carmen surname: Díez-Sánchez fullname: Díez-Sánchez, Carmen organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 4 givenname: Acisclo surname: Pérez-Martos fullname: Pérez-Martos, Acisclo organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 5 givenname: Julio surname: Montoya fullname: Montoya, Julio organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 6 givenname: Enrique surname: Alvarez fullname: Alvarez, Enrique organization: Unidad de Andrología. Hospital 12 de Octubre de Madrid, Spain – sequence: 7 givenname: Miguel surname: Díaz fullname: Díaz, Miguel organization: Clínica Ginecológica de Zaragoza, Spain – sequence: 8 givenname: Antonio surname: Urriés fullname: Urriés, Antonio organization: Nueva Clínica Quirón de Zaragoza, Zaragoza, Spain – sequence: 9 givenname: Luis surname: Montoro fullname: Montoro, Luis organization: Laboratorio de Reproducción Humana, Hospital Principe de Asturias, Alcalá de Henares, Madrid – sequence: 10 givenname: Manuel J. surname: López-Pérez fullname: López-Pérez, Manuel J. organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain – sequence: 11 givenname: José A. surname: Enríquez fullname: Enríquez, José A. email: enriquez@posta.unizar.es organization: Departamento de Bioquímica y Biología Molecular y Celular, Universidad de Zaragoza, Spain
BackLink	http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=1486063$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/10936107$$D View this record in MEDLINE/PubMed
BookMark	eNpdkMFO3DAQhi1EVRZoH6HKAfUWGNuxnVwqraCwlbatVOBsGWey6yqJg-1QwdM3aFewcBrJ8-kf_98h2e99j4R8pnBKoZRnHDgUsEdmVHCVSwlin8wAgOUVq9QBOYzxLwClJfCP5IBCxSUFNSPLxdiZPuvSxa95tjBD61fBj0PM5jF660zCOvvn0jpbuNU68yH7g_Vop8frAUNnkn_yJvvpk2tdejwmHxrTRvy0nUfk9vL7zfkiX_6--nE-X-a24CzlDZZ3ogZhC4kFg4bJRlG0gtWmaURVWOBYU8mNwamWrMRUQ1ZK2ULQiinOj8i3Te4w3nVYW-xTMK0egutMeNTeOP1207u1XvkHTVmpBCungK_bgODvR4xJdy5abFvTox-jVlRJoLugDT7GgM3LEQr6WbzeiJ_AL7tf2sE2pifgZAuYaE3bBNNbF1-5opQgn6vBBsPJ34PDoKN12E_GXUCbdO3d-9P_Aadrm44
CODEN	AJHGAG
CitedBy_id	crossref_primary_10_1086_320613 crossref_primary_10_1016_j_bbabio_2013_10_009 crossref_primary_10_1098_rspb_2014_1686 crossref_primary_10_1016_j_mito_2009_08_008 crossref_primary_10_1093_humupd_dmp016 crossref_primary_10_1016_j_gyobfe_2004_10_016 crossref_primary_10_1016_j_mito_2011_06_012 crossref_primary_10_3390_ijms24108848 crossref_primary_10_1111_j_1365_2605_2007_00786_x crossref_primary_10_1016_S0169_5347_01_02261_3 crossref_primary_10_1089_ars_2021_0238 crossref_primary_10_1016_j_bbrc_2004_07_112 crossref_primary_10_1016_S0140_6736_00_04452_4 crossref_primary_10_1111_acel_12186 crossref_primary_10_1038_ng1897 crossref_primary_10_1016_j_mito_2018_04_002 crossref_primary_10_1177_2284026520940518 crossref_primary_10_1038_s41598_019_46446_8 crossref_primary_10_1098_rstb_2019_0177 crossref_primary_10_3390_biology11121715 crossref_primary_10_1111_j_0014_3820_2002_tb00149_x crossref_primary_10_25557_2073_7998_2018_01_9_13 crossref_primary_10_1051_medsci_2004208_9779 crossref_primary_10_1080_19396368_2016_1263367 crossref_primary_10_1002_jez_b_20251 crossref_primary_10_1017_pcm_2022_8 crossref_primary_10_1111_j_1420_9101_2009_01913_x crossref_primary_10_1016_j_mito_2019_06_004 crossref_primary_10_1095_biolreprod_102_005140 crossref_primary_10_1097_QAD_0000000000000297 crossref_primary_10_1098_rstb_2019_0187 crossref_primary_10_1007_s10815_014_0187_2 crossref_primary_10_3389_fneur_2022_946559 crossref_primary_10_1186_s12711_016_0242_9 crossref_primary_10_1186_1471_2164_15_257 crossref_primary_10_1007_s43032_020_00408_y crossref_primary_10_1002_ajpa_20108 crossref_primary_10_1016_j_jri_2009_08_009 crossref_primary_10_1371_journal_pone_0135622 crossref_primary_10_1002_bies_201200141 crossref_primary_10_1038_sj_ejhg_5201250 crossref_primary_10_1016_j_gyobfe_2006_06_016 crossref_primary_10_1021_pr500652y crossref_primary_10_1016_j_mito_2008_10_002 crossref_primary_10_1097_RD9_0000000000000026 crossref_primary_10_1371_journal_pone_0252923 crossref_primary_10_1002_art_23659 crossref_primary_10_1038_srep33363 crossref_primary_10_1016_j_mito_2009_04_007 crossref_primary_10_1111_j_1365_2605_2004_00520_x crossref_primary_10_1111_sms_12612 crossref_primary_10_1002_jcp_21528 crossref_primary_10_1002_bem_20602 crossref_primary_10_1126_science_1201157 crossref_primary_10_1007_s00441_012_1444_2 crossref_primary_10_1016_j_ncl_2013_05_002 crossref_primary_10_1016_j_xfss_2022_02_003 crossref_primary_10_1111_j_1365_2605_2009_00987_x crossref_primary_10_1016_j_ibmb_2006_11_002 crossref_primary_10_1038_s41437_022_00554_w crossref_primary_10_1186_s13148_018_0590_0 crossref_primary_10_1038_s41598_019_56921_x crossref_primary_10_1111_jeb_13536 crossref_primary_10_1016_j_mito_2010_05_015 crossref_primary_10_1086_522811 crossref_primary_10_1101_sqb_2003_68_471 crossref_primary_10_1080_24701394_2024_2361609 crossref_primary_10_1097_QAI_0000000000001926 crossref_primary_10_1038_jhg_2016_130 crossref_primary_10_1111_j_1365_2443_2006_00986_x crossref_primary_10_1038_sj_ejhg_5200703 crossref_primary_10_1007_s10815_023_02721_2 crossref_primary_10_1371_journal_pone_0094991 crossref_primary_10_2217_epi_11_109 crossref_primary_10_1155_2014_560340 crossref_primary_10_1002_humu_20930 crossref_primary_10_23736_S2724_6507_21_03650_2 crossref_primary_10_1007_s10142_023_01023_1 crossref_primary_10_1534_genetics_116_187286 crossref_primary_10_1016_j_rbmo_2016_10_001 crossref_primary_10_1016_j_rbmo_2018_10_004 crossref_primary_10_1086_502682 crossref_primary_10_1093_humupd_dml011 crossref_primary_10_1554_0014_3820_2002_056_2252_HFOMGT_2_0_CO_2 crossref_primary_10_1371_journal_pgen_1004369 crossref_primary_10_1089_gtmb_2012_0052 crossref_primary_10_2174_1874085500801010010 crossref_primary_10_1016_j_cub_2019_03_020 crossref_primary_10_1086_501236 crossref_primary_10_1016_S0022_5347_05_00163_1 crossref_primary_10_1038_s41598_018_37944_2 crossref_primary_10_1111_j_1365_2605_2001_00311_x crossref_primary_10_1016_j_semcdb_2016_01_028 crossref_primary_10_3389_fmolb_2019_00128 crossref_primary_10_1016_j_bbrc_2014_06_020 crossref_primary_10_1097_SHK_0b013e3181a99508 crossref_primary_10_1016_S0014_5793_01_02199_8 crossref_primary_10_1177_1745691617718356 crossref_primary_10_1097_QAI_0b013e3181a324d6 crossref_primary_10_1093_molbev_msm004 crossref_primary_10_3389_fragi_2024_1361396 crossref_primary_10_1016_j_fertnstert_2007_10_059 crossref_primary_10_1016_j_neurobiolaging_2008_01_004 crossref_primary_10_1371_journal_pone_0052367 crossref_primary_10_1002_ece3_8366 crossref_primary_10_1042_BJ20061609 crossref_primary_10_1111_j_1558_5646_2009_00614_x crossref_primary_10_29413_ABS_2020_5_5_2 crossref_primary_10_1007_s00134_011_2319_9 crossref_primary_10_1095_biolreprod_106_059030 crossref_primary_10_1038_aja_2013_83 crossref_primary_10_1016_S0925_4439_02_00097_2 crossref_primary_10_1111_evo_12553 crossref_primary_10_1196_annals_1427_001 crossref_primary_10_1093_humrep_der317 crossref_primary_10_1093_humrep_der438 crossref_primary_10_1016_j_mito_2020_06_003 crossref_primary_10_1093_genetics_159_1_173 crossref_primary_10_1093_humrep_17_3_718 crossref_primary_10_3389_fgene_2014_00448 crossref_primary_10_1002_mrd_22197 crossref_primary_10_1186_1471_2474_12_283 crossref_primary_10_1556_oh_2007_28014 crossref_primary_10_1016_S0169_5347_01_02224_8 crossref_primary_10_1530_REP_17_0600 crossref_primary_10_1016_j_gene_2005_09_015 crossref_primary_10_1098_rspb_2017_2174 crossref_primary_10_1126_science_1088434 crossref_primary_10_1073_pnas_1421391112 crossref_primary_10_1007_s00296_014_3104_1 crossref_primary_10_1111_j_1365_294X_2009_04444_x crossref_primary_10_1007_s10709_007_9192_z crossref_primary_10_1016_j_bbagen_2013_10_036 crossref_primary_10_1038_ncomms5438 crossref_primary_10_1007_BF03349169 crossref_primary_10_1146_annurev_ecolsys_36_091704_175513 crossref_primary_10_1093_humupd_dmw028 crossref_primary_10_1007_s00702_008_0121_9 crossref_primary_10_1038_nrg774 crossref_primary_10_1007_s11357_011_9209_5 crossref_primary_10_1016_j_jinsphys_2009_05_010 crossref_primary_10_1111_j_1420_9101_2007_01433_x crossref_primary_10_1046_j_1365_2605_2002_00360_x crossref_primary_10_1111_ene_13860 crossref_primary_10_1016_j_tree_2013_12_003 crossref_primary_10_1016_j_mito_2007_10_007 crossref_primary_10_1007_s11033_013_2566_7 crossref_primary_10_1071_RD21343 crossref_primary_10_1098_rspb_2018_2708 crossref_primary_10_1111_febs_12466 crossref_primary_10_1111_and_13007 crossref_primary_10_1002_biot_200800046 crossref_primary_10_1098_rspb_2005_3411 crossref_primary_10_1002_stem_1313 crossref_primary_10_3390_genes9080395 crossref_primary_10_1038_sj_ejhg_5201438 crossref_primary_10_1111_j_1558_5646_2012_01683_x crossref_primary_10_1155_2013_631082 crossref_primary_10_3390_antiox11091684 crossref_primary_10_1038_nature18618 crossref_primary_10_1016_j_gene_2008_01_007 crossref_primary_10_1016_j_bbabio_2006_05_040 crossref_primary_10_1111_j_1365_2605_2005_00614_x crossref_primary_10_1002_bies_201100157 crossref_primary_10_1093_hmg_ddq246 crossref_primary_10_1016_j_mito_2018_10_004 crossref_primary_10_1016_j_ijcard_2005_09_008 crossref_primary_10_1093_humrep_der062 crossref_primary_10_1016_j_arcmed_2006_04_009 crossref_primary_10_1186_1471_2474_12_264 crossref_primary_10_4995_wrs_2018_7644 crossref_primary_10_1016_j_mito_2021_02_013 crossref_primary_10_1002_ddrr_113 crossref_primary_10_1016_j_exger_2016_07_010 crossref_primary_10_1016_j_isci_2022_105573 crossref_primary_10_1111_j_1365_2605_2006_00730_x crossref_primary_10_3390_biology12060827 crossref_primary_10_1016_j_parkreldis_2012_01_021 crossref_primary_10_1016_j_fertnstert_2007_03_048 crossref_primary_10_1016_j_mce_2013_06_005 crossref_primary_10_1016_j_mito_2011_04_005 crossref_primary_10_1093_evolut_qpad087 crossref_primary_10_1186_s12863_016_0375_4 crossref_primary_10_1016_j_cell_2015_08_067 crossref_primary_10_1186_s40104_018_0299_0 crossref_primary_10_1007_s00239_008_9078_4 crossref_primary_10_1016_j_bbabio_2004_08_003 crossref_primary_10_3390_genes13071182 crossref_primary_10_1093_icb_icz091 crossref_primary_10_1111_j_1365_2605_2005_00539_x crossref_primary_10_3390_ijms24010471 crossref_primary_10_1017_S1464793101005863 crossref_primary_10_1016_S0960_8966_01_00329_7 crossref_primary_10_1111_and_13666 crossref_primary_10_1371_journal_pone_0012037 crossref_primary_10_1038_sj_hdy_6800014 crossref_primary_10_1152_physiolgenomics_00029_2011 crossref_primary_10_1002_mrd_23640 crossref_primary_10_1016_j_mito_2013_08_004 crossref_primary_10_1186_1471_2350_10_35 crossref_primary_10_1002_iub_2434 crossref_primary_10_1038_s41559_017_0276_6 crossref_primary_10_1016_j_mito_2010_09_004 crossref_primary_10_1016_j_mito_2013_08_001 crossref_primary_10_1016_S1521_6934_02_00147_5 crossref_primary_10_1002_bies_200800139 crossref_primary_10_1098_rspb_2013_2549 crossref_primary_10_1016_j_mito_2015_07_007 crossref_primary_10_1016_j_rbmo_2010_03_026 crossref_primary_10_1111_j_1365_294X_2010_04594_x crossref_primary_10_1186_1471_2164_9_198 crossref_primary_10_1016_j_mito_2008_04_002 crossref_primary_10_1093_gbe_evt058 crossref_primary_10_1046_j_1365_294X_2003_02063_x crossref_primary_10_1191_1352458504ms1069oa crossref_primary_10_1007_s00109_010_0589_2 crossref_primary_10_1038_sj_tpj_6500470 crossref_primary_10_1111_j_1420_9101_2006_01189_x crossref_primary_10_1073_pnas_0136972100 crossref_primary_10_1101_gr_086462_108 crossref_primary_10_1111_j_1445_5994_2006_01118_x crossref_primary_10_1017_S0967199418000242 crossref_primary_10_1016_j_exger_2014_03_022 crossref_primary_10_1046_j_1439_0531_2003_00448_x crossref_primary_10_2478_v10125_010_0015_y crossref_primary_10_1002_bies_10062 crossref_primary_10_4061_2011_709061 crossref_primary_10_1038_srep42009 crossref_primary_10_1093_hmg_ddn303 crossref_primary_10_1016_S0014_5793_03_01013_5 crossref_primary_10_1093_eurheartj_ehr280 crossref_primary_10_18632_oncotarget_17675 crossref_primary_10_1016_j_jtbi_2009_06_004 crossref_primary_10_1002_elps_200600086 crossref_primary_10_1111_jzs_12381 crossref_primary_10_1016_j_bbagen_2013_11_013 crossref_primary_10_1016_j_mito_2014_03_001 crossref_primary_10_1186_s43141_020_00111_0 crossref_primary_10_1016_j_bbabio_2010_01_003 crossref_primary_10_1095_biolreprod_107_066357 crossref_primary_10_1093_rheumatology_kew394 crossref_primary_10_1016_j_arr_2010_06_003 crossref_primary_10_1097_TA_0b013e3181991ac8 crossref_primary_10_1002_ajmg_b_30687 crossref_primary_10_1038_cddiscovery_2017_62 crossref_primary_10_1098_rspb_2001_1925 crossref_primary_10_1093_gbe_evx235 crossref_primary_10_1097_SLA_0b013e3181469955 crossref_primary_10_1016_j_mito_2009_09_007 crossref_primary_10_1186_1471_2350_9_57 crossref_primary_10_1111_j_1420_9101_2008_01581_x crossref_primary_10_1038_ejhg_2017_114 crossref_primary_10_1093_humupd_dmh045 crossref_primary_10_1016_j_domaniend_2016_03_005 crossref_primary_10_3390_genes15050600 crossref_primary_10_1007_s10522_008_9186_y crossref_primary_10_1038_hdy_2011_8 crossref_primary_10_1038_ng759 crossref_primary_10_1134_S0006297915120032 crossref_primary_10_1046_j_1365_2605_2001_00311_x crossref_primary_10_1093_humupd_dmab001 crossref_primary_10_1016_S0378_1119_01_00812_5 crossref_primary_10_1016_j_arr_2014_10_007 crossref_primary_10_1016_j_mito_2009_12_146 crossref_primary_10_1016_j_mito_2020_11_007 crossref_primary_10_1016_j_neulet_2009_11_037 crossref_primary_10_1016_j_neulet_2004_08_012 crossref_primary_10_1111_j_1469_185X_2008_00068_x crossref_primary_10_1086_303061 crossref_primary_10_1212_WNL_0b013e3181a41269 crossref_primary_10_1134_S0026893310010048 crossref_primary_10_1016_j_tree_2004_02_002 crossref_primary_10_1177_1352458506070454 crossref_primary_10_1016_j_mito_2014_08_002 crossref_primary_10_1016_S0140_6736_05_67890_7 crossref_primary_10_1046_j_1420_9101_2003_00572_x crossref_primary_10_1007_s10522_018_9748_6 crossref_primary_10_4236_ijcm_2016_71005 crossref_primary_10_1371_journal_pone_0002091 crossref_primary_10_1007_s00702_007_0658_z crossref_primary_10_1530_REP_13_0178 crossref_primary_10_1158_1055_9965_EPI_07_0119 crossref_primary_10_1002_jez_a_122 crossref_primary_10_1086_339933 crossref_primary_10_1002_bies_1152 crossref_primary_10_1016_j_tig_2007_05_011 crossref_primary_10_1016_S0531_5131_03_01838_7 crossref_primary_10_1111_and_12304 crossref_primary_10_1093_humrep_dem030 crossref_primary_10_1111_j_1558_5646_2012_01675_x crossref_primary_10_7554_eLife_16923 crossref_primary_10_1038_s41420_022_01130_1 crossref_primary_10_1093_molbev_msl084 crossref_primary_10_1186_s12881_017_0438_z crossref_primary_10_1038_sj_ejhg_5200991 crossref_primary_10_1086_373936 crossref_primary_10_1093_hmg_ddt601 crossref_primary_10_7554_eLife_23551 crossref_primary_10_1016_j_bbrep_2016_08_002 crossref_primary_10_1177_1721727X1201000321 crossref_primary_10_4061_2011_814096 crossref_primary_10_1016_j_cub_2012_07_066 crossref_primary_10_1097_QAD_0b013e32831940bb crossref_primary_10_1530_REP_16_0342 crossref_primary_10_1097_CCM_0000000000003810 crossref_primary_10_1016_S0169_5347_00_02087_5 crossref_primary_10_1016_S1357_2725_02_00042_0 crossref_primary_10_1098_rstb_2013_0438 crossref_primary_10_1534_genetics_116_192328 crossref_primary_10_1111_j_1365_2605_2005_00515_x crossref_primary_10_1146_annurev_animal_080520_083353 crossref_primary_10_1186_s13618_014_0023_x crossref_primary_10_1111_andr_12889 crossref_primary_10_1016_j_mito_2007_12_002 crossref_primary_10_1016_j_pnpbp_2010_07_004 crossref_primary_10_1098_rstb_2013_0443 crossref_primary_10_1016_j_mito_2007_06_002 crossref_primary_10_1098_rstb_2013_0440 crossref_primary_10_1111_j_1558_5646_2012_01641_x crossref_primary_10_1016_j_bse_2004_12_003 crossref_primary_10_1016_S0210_5691_07_74804_0 crossref_primary_10_1093_genetics_iyad036 crossref_primary_10_1146_annurev_genet_35_102401_091106 crossref_primary_10_1093_gerona_glr056 crossref_primary_10_1002_humu_20338 crossref_primary_10_1016_j_mito_2009_11_005 crossref_primary_10_1111_rda_12901 crossref_primary_10_1134_S102279540601011X
Cites_doi	10.1128/MCB.20.3.805-815.2000 10.1016/0925-4439(94)90058-2 10.1093/clinchem/44.8.1616 10.1172/JCI116267 10.1093/hmg/6.11.1835 10.1023/A:1006856407698 10.1071/RD9940009 10.1038/13779 10.1111/j.1600-0404.1996.tb07048.x 10.1038/ng0793-289 10.1016/S0074-7696(08)61051-7 10.1093/genetics/144.4.1835 10.1016/0005-2728(85)90014-3 10.1095/biolreprod52.4.729 10.1038/nm0297-124c 10.1093/molehr/3.2.133 10.1016/S0140-6736(05)79190-X 10.1046/j.1365-2605.1998.00093.x 10.1128/MCB.18.10.5868 10.1006/geno.1996.4474 10.1038/ng0595-47 10.1086/302204 10.1007/BF00206061 10.1530/jrf.0.0630271 10.1002/humu.1380030311 10.1023/A:1022685929755 10.1146/annurev.ge.29.120195.001055 10.1093/clinchem/31.5.754 10.1007/BF01200999 10.1093/oxfordjournals.humrep.a137950 10.1073/pnas.94.4.1166 10.1016/0196-0709(95)90078-0 10.1038/383224a0 10.1093/hmg/5.7.963 10.1177/135245859500100106 10.1055/s-2007-973557 10.1093/hmg/6.3.443 10.1096/fasebj.13.12.1532 10.1038/ng0597-93 10.1038/ng0994-95
ContentType	Journal Article
Copyright	2000 The American Society of Human Genetics 2000 INIST-CNRS 2000 by The American Society of Human Genetics. All rights reserved. 2000
Copyright_xml	– notice: 2000 The American Society of Human Genetics – notice: 2000 INIST-CNRS – notice: 2000 by The American Society of Human Genetics. All rights reserved. 2000
DBID	6I. AAFTH IQODW CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM
DOI	10.1086/303040
DatabaseName	ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Pascal-Francis Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic PubMed Central (Full Participant titles)
DatabaseTitle	MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic
DatabaseTitleList	MEDLINE
Database_xml	– sequence: 1 dbid: ECM name: MEDLINE url: https://search.ebscohost.com/login.aspx?direct=true&db=cmedm&site=ehost-live sourceTypes: Index Database
DeliveryMethod	fulltext_linktorsrc
Discipline	Biology
DocumentTitleAlternate	mtDNA Haplogroups and Spermatozoa Motility
EISSN	1537-6605
EndPage	696
ExternalDocumentID	10_1086_303040 10936107 1486063 S0002929707632558
Genre	Research Support, Non-U.S. Gov't Journal Article
GroupedDBID	--- --K --Z -~X .55 .GJ 0R~ 123 1~5 23M 2WC 34R 3O- 4.4 41~ 457 4G. 53G 5GY 62- 6I. 6J9 7-5 85S AACTN AAEDT AAEDW AAFTH AAIAV AAIKJ AAKRW AALRI AAQXK AAUCE AAVLU AAWTL AAXJY AAXUO ABJNI ABMAC ABMWF ABOCM ABVKL ACGFO ACGFS ACGOD ACKIV ACNCT ACPRK ADBBV ADEZE ADJPV ADMUD AENEX AEXQZ AFMIJ AFRAH AFTJW AGCDD AGHFR AGKMS AHMBA AI. AITUG ALKID ALMA_UNASSIGNED_HOLDINGS AMRAJ AOIJS ASPBG AVWKF AZFZN BAWUL C1A CS3 D0L DIK E3Z EBS ECV EJD F20 F5P FA8 FCP FDB FEDTE FGOYB GX1 HVGLF HYE HZ~ IH2 IHE IXB JIG KQ8 L7B M41 MVM NCXOZ NEJ O-L O9- OHT OK1 OZT P2P PQQKQ R2- RCE RIG RNS ROL RPM RPZ SES SJN SSZ TN5 TR2 TWZ UHB UKR UNMZH UPT VH1 VQA WH7 WOQ WQ6 X7M XOL ZA5 ZCA ZCG ZGI ZXP 08R AAUGY ABPTK AKALU IQODW 0SF AAMRU ADVLN AKAPO AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 5PM
ID	FETCH-LOGICAL-c432t-fe8b5d05c46e420f26f71ec52daff594c03ed163aae3036950026977c45192733
IEDL.DBID	RPM
ISSN	0002-9297
IngestDate	Tue Sep 17 20:59:00 EDT 2024 Fri Oct 25 23:19:41 EDT 2024 Thu Nov 21 23:04:00 EST 2024 Sat Sep 28 07:39:57 EDT 2024 Sun Oct 29 17:10:08 EDT 2023 Fri Feb 23 02:34:47 EST 2024
IsDoiOpenAccess	true
IsOpenAccess	true
IsPeerReviewed	true
IsScholarly	true
Issue	3
Keywords	Human Spermatozoa Pathogenesis Mobility Exploration Mitochondrial DNA Genetic determinism Semen disorders Oligospermia Male sterility Mutation Asthenospermia Caucasoid Male genital diseases Haplotype
Language	English
License	http://www.elsevier.com/open-access/userlicense/1.0 CC BY 4.0
LinkModel	DirectLink
MergedId	FETCHMERGED-LOGICAL-c432t-fe8b5d05c46e420f26f71ec52daff594c03ed163aae3036950026977c45192733
Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
OpenAccessLink	https://dx.doi.org/10.1086/303040
PMID	10936107
PQID	71760128
PQPubID	23479
PageCount	15
ParticipantIDs	pubmedcentral_primary_oai_pubmedcentral_nih_gov_1287528 proquest_miscellaneous_71760128 crossref_primary_10_1086_303040 pubmed_primary_10936107 pascalfrancis_primary_1486063 elsevier_sciencedirect_doi_10_1086_303040
PublicationCentury	2000
PublicationDate	2000-09-01
PublicationDateYYYYMMDD	2000-09-01
PublicationDate_xml	– month: 09 year: 2000 text: 2000-09-01 day: 01
PublicationDecade	2000
PublicationPlace	Chicago, IL
PublicationPlace_xml	– name: Chicago, IL – name: United States
PublicationTitle	American journal of human genetics
PublicationTitleAlternate	Am J Hum Genet
PublicationYear	2000
Publisher	Elsevier Inc University of Chicago Press The American Society of Human Genetics
Publisher_xml	– name: Elsevier Inc – name: University of Chicago Press – name: The American Society of Human Genetics
References	Ford, Harrison (bib10) 1981; 63 Frank, Hurst (bib11) 1996; 383 Larsson, Clayton (bib23) 1995; 29 Ruiz-Pesini, Diez, Lapena, Perez-Martos, Montoya, Alvarez, Arenas, López-Pérez (bib37) 1998; 44 Majamaa, Finnila, Turkka, Hassinen (bib25) 1998; 352 Hofmann, Bezold, Jaksch, Kaufhold, Obermaier-Kusser, Gerbitz (bib15) 1997 ; 174 Torroni, Petrozzi, D'Urbano, Sellitto, Zeviani, Carrara, Carducci, Leuzzi, Carelli, Barboni, De Negri, Scozzari (bib41) 1997; 60 Bai, Shakeley, Attardi (bib2) 2000; 20 Guan, Fischel-Ghodsian, Attardi (bib13) 1996; 5 Ohlenbusch, Wilichowski, Hanefeld (bib28) 1998; 29 Hofmann, Bezold, Jaksch, Obermaier-Kusser, Mertens, Kaufhold, Rabl, Hecker, Gerbitz (bib16) 1997 ; 39 Villani, Attardi (bib42) 1997; 94 Rötig, Cormier, Chatelain, Francois, Saudubray, Rustin, Munnich (bib36) 1993; 91 Enriquez, Chomyn, Attardi (bib7) 1995; 10 Fischel-Ghodsian, Prezant, Fournier, Stewart, Maw (bib8) 1995; 16 Marzuki, Noer, Lertrit, Thyagarajan, Kapsa, Utthanaphol, Byrne (bib26) 1991; 88 WHO (bib44) 1992 Houshmand, Larsson, Holme, Oldfors, Tulinius, Andersen (bib18) 1994; 1226 Mayr-Wohlfart, Paulus, Henneberg, Rodel (bib27) 1996; 94 Følgero, Bertheussen, Lindal, Torbergsen, Oian (bib9) 1993; 8 Jenuth, Peterson, Shoubridge (bib20) 1997; 16 Kalman, Lublin, Alder (bib21) 1995; 1 Kao, Chao, Wei (bib22) 1995; 52 Brown, Sun, Wallace (bib4) 1997; 60 Howell (bib19) 1999; 186 Halangk, Bohnensack, Kunz (bib14) 1985; 808 Reid, Rovio, Holt, Jacobs (bib32) 1997; 6 Hofmann, Jaksch, Bezold, Mertens, Aholt, Paprotta, Gerbitz (bib17) 1997 ; 6 St. John, Cooke, Barratt (bib39) 1997; 3 Guan, Enriquez, Fischel-Ghodsian, Puranam, Lin, Maw, Attardi (bib12) 1998; 18 Polymeropoulos, Swift, Swift (bib30) 1994; 8 Rodriguez-Segade, de la Pena, Paz, Del Rio (bib35) 1985; 31 Zeviani, Antozzi (bib45) 1997; 3 Schon, Bonilla, DiMauro (bib38) 1997; 29 Wallace (bib43) 1995; 57 Baker (bib3) 1994; 6 Andrews, Kubacka, Chinnery, Lightowlers, Turnbull, Howell (bib1) 1999; 23 Prezant, Agapian, Bohlman, Bu, Oztas, Qiu, Arnos, Cortopassi, Jaber, Roteer, Shohat, Fischel-Ghodsian (bib31) 1993; 4 Cummins, Jequier, Martin, Mehmet, Goldblatt (bib5) 1998; 21 Macaulay, Richards, Hickey, Vega, Cruciani, Guida, Scozzari, Bonne-Tamir, Sykes, Torroni (bib24) 1999; 64 Pascual, Cebrian-Perez, Lopez-Perez, Muino-Blanco (bib29) 1996; 16 Richards, Corte-Real, Forster, Macaulay, Wilkinson-Herbots, Demaine, Papiha, Hedges, Bandelt, Sykes (bib34) 1996; 59 Torroni, Huoponen, Francalacci, Petrozzi, Morelli, Scozzari, Obinu, Savontaus, Wallace (bib40) 1996; 144 Reid, Vernham, Jacobs (bib33) 1994; 3 De Benedictis, Rose, Carrieri, De Luca, Falcone, Passarino, Bonafe, Monti, Baggio, Bertolini, Mari, Mattace, Franceschi (bib6) 1999; 13 8825472 - Annu Rev Genet. 1995;29:151-78 11359216 - Am J Hum Genet. 2001 Jun;68(6):1535-7 9762692 - Neuropediatrics. 1998 Aug;29(4):175-9 9302261 - Hum Mol Genet. 1997 Oct;6(11):1835-46 8805695 - Nature. 1996 Sep 19;383(6597):224 9345467 - Mult Scler. 1995 Apr;1(1):32-6 8899049 - Acta Neurol Scand. 1996 Sep;94(3):167-71 9915963 - Am J Hum Genet. 1999 Jan;64(1):232-49 1757091 - Hum Genet. 1991 Dec;88(2):139-45 9239539 - J Bioenerg Biomembr. 1997 Apr;29(2):131-49 8288752 - Hum Reprod. 1993 Nov;8(11):1863-8 9708761 - Lancet. 1998 Aug 8;352(9126):455-6 8066228 - Reprod Fertil Dev. 1994;6(1):9-12 8978068 - Genetics. 1996 Dec;144(4):1835-50 3848331 - Biochim Biophys Acta. 1985 Jul 17;808(2):316-22 10508508 - Nat Genet. 1999 Oct;23(2):147 9742104 - Mol Cell Biol. 1998 Oct;18(10):5868-79 7668244 - Am J Hum Genet. 1995 Aug;57(2):201-23 9027481 - Genomics. 1997 Jan 1;39(1):8-18 9012411 - Am J Hum Genet. 1997 Feb;60(2):381-7 7987399 - Nat Genet. 1994 Sep;8(1):95-7 9147648 - Hum Mol Genet. 1997 Mar;6(3):443-9 9140402 - Nat Genet. 1997 May;16(1):93-5 7647790 - Nat Genet. 1995 May;10(1):47-55 8572257 - Am J Otolaryngol. 1995 Nov-Dec;16(6):403-8 9150158 - Am J Hum Genet. 1997 May;60(5):1107-21 9702947 - Clin Chem. 1998 Aug;44(8 Pt 1):1616-20 9037024 - Proc Natl Acad Sci U S A. 1997 Feb 18;94(4):1166-71 7277330 - J Reprod Fertil. 1981 Sep;63(1):271-8 8861538 - Biosci Rep. 1996 Feb;16(1):35-40 9309689 - Mol Cell Biochem. 1997 Sep;174(1-2):209-13 8659525 - Am J Hum Genet. 1996 Jul;59(1):185-203 10463944 - FASEB J. 1999 Sep;13(12):1532-6 10629037 - Mol Cell Biol. 2000 Feb;20(3):805-15 8817331 - Hum Mol Genet. 1996 Jul;5(7):963-71 9239718 - Mol Hum Reprod. 1997 Feb;3(2):133-48 7779994 - Biol Reprod. 1995 Apr;52(4):729-36 9639152 - Int J Androl. 1998 Feb;21(1):47-52 9770297 - Int Rev Cytol. 1999;186:49-116 7689389 - Nat Genet. 1993 Jul;4(3):289-94 3987004 - Clin Chem. 1985 May;31(5):754-7 9018221 - Nat Med. 1997 Feb;3(2):124-5 10936105 - Am J Hum Genet. 2000 Sep;67(3):543-8 8155739 - Biochim Biophys Acta. 1994 Apr 12;1226(1):49-55 8383698 - J Clin Invest. 1993 Mar;91(3):1095-8 8019558 - Hum Mutat. 1994;3(3):243-7 Polymeropoulos (10.1086/303040_bib30) 1994; 8 Enriquez (10.1086/303040_bib7) 1995; 10 Zeviani (10.1086/303040_bib45) 1997; 3 Hofmann (10.1086/303040_bib17) 1997; 6 Villani (10.1086/303040_bib42) 1997; 94 Cummins (10.1086/303040_bib5) 1998; 21 Wallace (10.1086/303040_bib43) 1995; 57 Larsson (10.1086/303040_bib23) 1995; 29 Mayr-Wohlfart (10.1086/303040_bib27) 1996; 94 WHO (10.1086/303040_bib44) 1992 Baker (10.1086/303040_bib3) 1994; 6 Ford (10.1086/303040_bib10) 1981; 63 Frank (10.1086/303040_bib11) 1996; 383 Hofmann (10.1086/303040_bib16) 1997; 39 Prezant (10.1086/303040_bib31) 1993; 4 Bai (10.1086/303040_bib2) 2000; 20 Følgero (10.1086/303040_bib9) 1993; 8 Houshmand (10.1086/303040_bib18) 1994; 1226 Ruiz-Pesini (10.1086/303040_bib37) 1998; 44 Rodriguez-Segade (10.1086/303040_bib35) 1985; 31 De Benedictis (10.1086/303040_bib6) 1999; 13 Schon (10.1086/303040_bib38) 1997; 29 Guan (10.1086/303040_bib12) 1998; 18 Halangk (10.1086/303040_bib14) 1985; 808 Marzuki (10.1086/303040_bib26) 1991; 88 Guan (10.1086/303040_bib13) 1996; 5 Reid (10.1086/303040_bib32) 1997; 6 Torroni (10.1086/303040_bib40) 1996; 144 Brown (10.1086/303040_bib4) 1997; 60 Ohlenbusch (10.1086/303040_bib28) 1998; 29 Rötig (10.1086/303040_bib36) 1993; 91 St. John (10.1086/303040_bib39) 1997; 3 Torroni (10.1086/303040_bib41) 1997; 60 Hofmann (10.1086/303040_bib15) 1997; 174 Fischel-Ghodsian (10.1086/303040_bib8) 1995; 16 Kalman (10.1086/303040_bib21) 1995; 1 Macaulay (10.1086/303040_bib24) 1999; 64 Richards (10.1086/303040_bib34) 1996; 59 Kao (10.1086/303040_bib22) 1995; 52 Majamaa (10.1086/303040_bib25) 1998; 352 Jenuth (10.1086/303040_bib20) 1997; 16 Pascual (10.1086/303040_bib29) 1996; 16 Andrews (10.1086/303040_bib1) 1999; 23 Howell (10.1086/303040_bib19) 1999; 186 Reid (10.1086/303040_bib33) 1994; 3
References_xml	– volume: 88 start-page: 139 year: 1991 end-page: 145 ident: bib26 article-title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base publication-title: Hum Genet contributor: fullname: Byrne – volume: 59 start-page: 185 year: 1996 end-page: 203 ident: bib34 article-title: Paleolithic and neolithic lineages in the European mitochondrial gene pool publication-title: Am J Hum Genet contributor: fullname: Sykes – volume: 16 start-page: 93 year: 1997 end-page: 95 ident: bib20 article-title: Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice publication-title: Nat Genet contributor: fullname: Shoubridge – volume: 31 start-page: 754 year: 1985 end-page: 757 ident: bib35 article-title: Determination of L-carnitine in serum, and implementation on the ABA-100 and CentrifiChem 600 publication-title: Clin Chem contributor: fullname: Del Rio – volume: 6 start-page: 9 year: 1994 end-page: 12 ident: bib3 article-title: Clinical male infertility. II. Critical evaluation of the prospects for therapy publication-title: Reprod Fertil Dev contributor: fullname: Baker – volume: 186 start-page: 49 year: 1999 end-page: 116 ident: bib19 article-title: Human mitochondrial diseases: answering questions and questioning answers publication-title: Int Rev Cytol contributor: fullname: Howell – volume: 1 start-page: 32 year: 1995 end-page: 36 ident: bib21 article-title: Mitochondrial DNA mutations in multiple sclerosis publication-title: Mult Scler contributor: fullname: Alder – volume: 60 start-page: 1107 year: 1997 end-page: 1121 ident: bib41 article-title: Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484 publication-title: Am J Hum Genet contributor: fullname: Scozzari – volume: 94 start-page: 167 year: 1996 end-page: 171 ident: bib27 article-title: Mitochondrial DNA mutations in multiple sclerosis patients with severe optic involvement publication-title: Acta Neurol Scand contributor: fullname: Rodel – volume: 16 start-page: 403 year: 1995 end-page: 408 ident: bib8 article-title: Mitochondrial mutation associated with nonsyndromic deafness publication-title: Am J Otolaryngol contributor: fullname: Maw – volume: 64 start-page: 232 year: 1999 end-page: 249 ident: bib24 article-title: The emerging tree of West Eurasian mtDNAs: a synthesis of control- region sequences and RFLPs publication-title: Am J Hum Genet contributor: fullname: Torroni – volume: 5 start-page: 963 year: 1996 end-page: 971 ident: bib13 article-title: Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation publication-title: Hum Mol Genet contributor: fullname: Attardi – volume: 20 start-page: 805 year: 2000 end-page: 815 ident: bib2 article-title: Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria publication-title: Mol Cell Biol contributor: fullname: Attardi – volume: 6 start-page: 1835 year: 1997 end-page: 1846 ident: bib17 article-title: Population genetics and disease susceptibility: characterization of central European haplogroups by mtDNA gene mutations, correlation with D loop variants and association with disease publication-title: Hum Mol Genet contributor: fullname: Gerbitz – volume: 29 start-page: 151 year: 1995 end-page: 178 ident: bib23 article-title: Molecular genetic aspects of human mitochondrial disorders publication-title: Annu Rev Genet contributor: fullname: Clayton – volume: 29 start-page: 131 year: 1997 end-page: 149 ident: bib38 article-title: Mitochondrial DNA mutations and pathogenesis publication-title: J Bioenerg Biomembrane contributor: fullname: DiMauro – volume: 144 start-page: 1835 year: 1996 end-page: 1850 ident: bib40 article-title: Classification of European mtDNAs from an analysis of three European populations publication-title: Genetics contributor: fullname: Wallace – volume: 3 start-page: 133 year: 1997 end-page: 148 ident: bib45 article-title: Mitochondrial disorders publication-title: Mol Hum Reprod contributor: fullname: Antozzi – volume: 39 start-page: 8 year: 1997 end-page: 18 ident: bib16 article-title: Wolfram (DIDMOAD) syndrome and Leber hereditary optic neuropathy (LHON) are associated with distinct mitochondrial DNA haplotypes publication-title: Genomics contributor: fullname: Gerbitz – volume: 52 start-page: 729 year: 1995 end-page: 736 ident: bib22 article-title: Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm publication-title: Biol Reprod contributor: fullname: Wei – volume: 4 start-page: 289 year: 1993 end-page: 294 ident: bib31 article-title: Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness publication-title: Nat Genet contributor: fullname: Fischel-Ghodsian – volume: 63 start-page: 271 year: 1981 end-page: 278 ident: bib10 article-title: The role of oxidative phosphorylation in the generation of ATP in human spermatozoa publication-title: J Reprod Fertil contributor: fullname: Harrison – volume: 13 start-page: 1532 year: 1999 end-page: 1536 ident: bib6 article-title: Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans publication-title: Faseb J contributor: fullname: Franceschi – volume: 352 start-page: 455 year: 1998 end-page: 456 ident: bib25 article-title: Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine publication-title: Lancet contributor: fullname: Hassinen – volume: 10 start-page: 47 year: 1995 end-page: 55 ident: bib7 article-title: MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination publication-title: Nat Genet contributor: fullname: Attardi – volume: 3 start-page: 124 year: 1997 end-page: 125 ident: bib39 article-title: Mitochondrial mutations and male infertility publication-title: Nat Med contributor: fullname: Barratt – volume: 60 start-page: 381 year: 1997 end-page: 387 ident: bib4 article-title: Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage publication-title: Am J Hum Genet contributor: fullname: Wallace – volume: 18 start-page: 5868 year: 1998 end-page: 5879 ident: bib12 article-title: The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression publication-title: Mol Cell Biol contributor: fullname: Attardi – volume: 16 start-page: 35 year: 1996 end-page: 40 ident: bib29 article-title: Short-term inhibition of the energy metabolism affects motility but not surface properties of sperm cells publication-title: Biosci Rep contributor: fullname: Muino-Blanco – volume: 8 start-page: 1863 year: 1993 end-page: 1868 ident: bib9 article-title: Mitochondrial Disease and Reduced Sperm Motility publication-title: Hum Reprod contributor: fullname: Oian – year: 1992 ident: bib44 publication-title: World Health Organization laboratory manual for the examination of human semen and sperm-cervical mucus interactions contributor: fullname: WHO – volume: 808 start-page: 316 year: 1985 end-page: 322 ident: bib14 article-title: Interdependence of mitochondrial ATP production and extramitochondrial ATP utilization in intact spermatozoa publication-title: Biochim Biophys Acta contributor: fullname: Kunz – volume: 8 start-page: 95 year: 1994 end-page: 97 ident: bib30 article-title: Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4 publication-title: Nat Genet contributor: fullname: Swift – volume: 94 start-page: 1166 year: 1997 end-page: 1171 ident: bib42 article-title: In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells publication-title: Proc Natl Acad Sci USA contributor: fullname: Attardi – volume: 57 start-page: 201 year: 1995 end-page: 223 ident: bib43 article-title: Mitochondrial DNA variation in human evolution, degenerative disease, and aging publication-title: Am J Hum Genet contributor: fullname: Wallace – volume: 383 start-page: 224 year: 1996 ident: bib11 article-title: Mitochondria and male disease publication-title: Nature contributor: fullname: Hurst – volume: 44 start-page: 1616 year: 1998 end-page: 1620 ident: bib37 article-title: Correlation of sperm motility with mitochondrial enzymatic activities publication-title: Clin Chem contributor: fullname: López-Pérez – volume: 91 start-page: 1095 year: 1993 end-page: 1098 ident: bib36 article-title: Deletion of Mitochondrial DNA in a case of early-onset diabetes-mellitus, optic atrophy, and deafness (Wolfram syndrome, MIM 222300) publication-title: J Clin Invest contributor: fullname: Munnich – volume: 3 start-page: 243 year: 1994 end-page: 247 ident: bib33 article-title: A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness publication-title: Hum Mutat contributor: fullname: Jacobs – volume: 174 start-page: 209 year: 1997 end-page: 213 ident: bib15 article-title: Analysis of the mitochondrial DNA from patients with Wolfram (DIDMOAD) syndrome publication-title: Mol Cell Biochem contributor: fullname: Gerbitz – volume: 21 start-page: 47 year: 1998 end-page: 52 ident: bib5 article-title: Semen levels of mitochondrial DNA deletions in men attending an infertility clinic do not correlate with phenotype publication-title: Int J Androl contributor: fullname: Goldblatt – volume: 1226 start-page: 49 year: 1994 end-page: 55 ident: bib18 article-title: Automatic sequencing of mitochondrial tRNA genes in patients with mitochondrial encephalomyopathy publication-title: Biochim Biophys Acta contributor: fullname: Andersen – volume: 6 start-page: 443 year: 1997 end-page: 449 ident: bib32 article-title: Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation publication-title: Hum Mol Genet contributor: fullname: Jacobs – volume: 29 start-page: 175 year: 1998 end-page: 179 ident: bib28 article-title: Characterization of the mitochondrial genome in childhood multiple sclerosis I. Optic neuritis and LHON mutations publication-title: Neuropediatrics contributor: fullname: Hanefeld – volume: 23 start-page: 147 year: 1999 ident: bib1 article-title: Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA publication-title: Nat Genet contributor: fullname: Howell – volume: 20 start-page: 805 year: 2000 ident: 10.1086/303040_bib2 article-title: Tight control of respiration by NADH dehydrogenase ND5 subunit gene expression in mouse mitochondria publication-title: Mol Cell Biol doi: 10.1128/MCB.20.3.805-815.2000 contributor: fullname: Bai – volume: 1226 start-page: 49 year: 1994 ident: 10.1086/303040_bib18 article-title: Automatic sequencing of mitochondrial tRNA genes in patients with mitochondrial encephalomyopathy publication-title: Biochim Biophys Acta doi: 10.1016/0925-4439(94)90058-2 contributor: fullname: Houshmand – volume: 44 start-page: 1616 year: 1998 ident: 10.1086/303040_bib37 article-title: Correlation of sperm motility with mitochondrial enzymatic activities publication-title: Clin Chem doi: 10.1093/clinchem/44.8.1616 contributor: fullname: Ruiz-Pesini – volume: 91 start-page: 1095 year: 1993 ident: 10.1086/303040_bib36 article-title: Deletion of Mitochondrial DNA in a case of early-onset diabetes-mellitus, optic atrophy, and deafness (Wolfram syndrome, MIM 222300) publication-title: J Clin Invest doi: 10.1172/JCI116267 contributor: fullname: Rötig – volume: 6 start-page: 1835 year: 1997 ident: 10.1086/303040_bib17 article-title: Population genetics and disease susceptibility: characterization of central European haplogroups by mtDNA gene mutations, correlation with D loop variants and association with disease publication-title: Hum Mol Genet doi: 10.1093/hmg/6.11.1835 contributor: fullname: Hofmann – volume: 174 start-page: 209 year: 1997 ident: 10.1086/303040_bib15 article-title: Analysis of the mitochondrial DNA from patients with Wolfram (DIDMOAD) syndrome publication-title: Mol Cell Biochem doi: 10.1023/A:1006856407698 contributor: fullname: Hofmann – volume: 59 start-page: 185 year: 1996 ident: 10.1086/303040_bib34 article-title: Paleolithic and neolithic lineages in the European mitochondrial gene pool publication-title: Am J Hum Genet contributor: fullname: Richards – volume: 6 start-page: 9 year: 1994 ident: 10.1086/303040_bib3 article-title: Clinical male infertility. II. Critical evaluation of the prospects for therapy publication-title: Reprod Fertil Dev doi: 10.1071/RD9940009 contributor: fullname: Baker – year: 1992 ident: 10.1086/303040_bib44 contributor: fullname: WHO – volume: 23 start-page: 147 year: 1999 ident: 10.1086/303040_bib1 article-title: Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA publication-title: Nat Genet doi: 10.1038/13779 contributor: fullname: Andrews – volume: 94 start-page: 167 year: 1996 ident: 10.1086/303040_bib27 article-title: Mitochondrial DNA mutations in multiple sclerosis patients with severe optic involvement publication-title: Acta Neurol Scand doi: 10.1111/j.1600-0404.1996.tb07048.x contributor: fullname: Mayr-Wohlfart – volume: 4 start-page: 289 year: 1993 ident: 10.1086/303040_bib31 article-title: Mitochondrial ribosomal RNA mutation associated with both antibiotic-induced and non-syndromic deafness publication-title: Nat Genet doi: 10.1038/ng0793-289 contributor: fullname: Prezant – volume: 186 start-page: 49 year: 1999 ident: 10.1086/303040_bib19 article-title: Human mitochondrial diseases: answering questions and questioning answers publication-title: Int Rev Cytol doi: 10.1016/S0074-7696(08)61051-7 contributor: fullname: Howell – volume: 144 start-page: 1835 year: 1996 ident: 10.1086/303040_bib40 article-title: Classification of European mtDNAs from an analysis of three European populations publication-title: Genetics doi: 10.1093/genetics/144.4.1835 contributor: fullname: Torroni – volume: 60 start-page: 381 year: 1997 ident: 10.1086/303040_bib4 article-title: Clustering of Caucasian Leber hereditary optic neuropathy patients containing the 11778 or 14484 mutations on an mtDNA lineage publication-title: Am J Hum Genet contributor: fullname: Brown – volume: 808 start-page: 316 year: 1985 ident: 10.1086/303040_bib14 article-title: Interdependence of mitochondrial ATP production and extramitochondrial ATP utilization in intact spermatozoa publication-title: Biochim Biophys Acta doi: 10.1016/0005-2728(85)90014-3 contributor: fullname: Halangk – volume: 52 start-page: 729 year: 1995 ident: 10.1086/303040_bib22 article-title: Mitochondrial deoxyribonucleic acid 4977-bp deletion is associated with diminished fertility and motility of human sperm publication-title: Biol Reprod doi: 10.1095/biolreprod52.4.729 contributor: fullname: Kao – volume: 3 start-page: 124 year: 1997 ident: 10.1086/303040_bib39 article-title: Mitochondrial mutations and male infertility publication-title: Nat Med doi: 10.1038/nm0297-124c contributor: fullname: St. John – volume: 3 start-page: 133 year: 1997 ident: 10.1086/303040_bib45 article-title: Mitochondrial disorders publication-title: Mol Hum Reprod doi: 10.1093/molehr/3.2.133 contributor: fullname: Zeviani – volume: 352 start-page: 455 year: 1998 ident: 10.1086/303040_bib25 article-title: Mitochondrial DNA haplogroup U as a risk factor for occipital stroke in migraine publication-title: Lancet doi: 10.1016/S0140-6736(05)79190-X contributor: fullname: Majamaa – volume: 21 start-page: 47 year: 1998 ident: 10.1086/303040_bib5 article-title: Semen levels of mitochondrial DNA deletions in men attending an infertility clinic do not correlate with phenotype publication-title: Int J Androl doi: 10.1046/j.1365-2605.1998.00093.x contributor: fullname: Cummins – volume: 18 start-page: 5868 year: 1998 ident: 10.1086/303040_bib12 article-title: The deafness-associated mitochondrial DNA mutation at position 7445, which affects tRNASer(UCN) precursor processing, has long-range effects on NADH dehydrogenase subunit ND6 gene expression publication-title: Mol Cell Biol doi: 10.1128/MCB.18.10.5868 contributor: fullname: Guan – volume: 39 start-page: 8 year: 1997 ident: 10.1086/303040_bib16 article-title: Wolfram (DIDMOAD) syndrome and Leber hereditary optic neuropathy (LHON) are associated with distinct mitochondrial DNA haplotypes publication-title: Genomics doi: 10.1006/geno.1996.4474 contributor: fullname: Hofmann – volume: 10 start-page: 47 year: 1995 ident: 10.1086/303040_bib7 article-title: MtDNA mutation in MERRF syndrome causes defective aminoacylation of tRNA(Lys) and premature translation termination publication-title: Nat Genet doi: 10.1038/ng0595-47 contributor: fullname: Enriquez – volume: 64 start-page: 232 year: 1999 ident: 10.1086/303040_bib24 article-title: The emerging tree of West Eurasian mtDNAs: a synthesis of control- region sequences and RFLPs publication-title: Am J Hum Genet doi: 10.1086/302204 contributor: fullname: Macaulay – volume: 60 start-page: 1107 year: 1997 ident: 10.1086/303040_bib41 article-title: Haplotype and phylogenetic analyses suggest that one European-specific mtDNA background plays a role in the expression of Leber hereditary optic neuropathy by increasing the penetrance of the primary mutations 11778 and 14484 publication-title: Am J Hum Genet contributor: fullname: Torroni – volume: 88 start-page: 139 year: 1991 ident: 10.1086/303040_bib26 article-title: Normal variants of human mitochondrial DNA and translation products: the building of a reference data base publication-title: Hum Genet doi: 10.1007/BF00206061 contributor: fullname: Marzuki – volume: 63 start-page: 271 year: 1981 ident: 10.1086/303040_bib10 article-title: The role of oxidative phosphorylation in the generation of ATP in human spermatozoa publication-title: J Reprod Fertil doi: 10.1530/jrf.0.0630271 contributor: fullname: Ford – volume: 3 start-page: 243 year: 1994 ident: 10.1086/303040_bib33 article-title: A novel mitochondrial point mutation in a maternal pedigree with sensorineural deafness publication-title: Hum Mutat doi: 10.1002/humu.1380030311 contributor: fullname: Reid – volume: 29 start-page: 131 year: 1997 ident: 10.1086/303040_bib38 article-title: Mitochondrial DNA mutations and pathogenesis publication-title: J Bioenerg Biomembrane doi: 10.1023/A:1022685929755 contributor: fullname: Schon – volume: 29 start-page: 151 year: 1995 ident: 10.1086/303040_bib23 article-title: Molecular genetic aspects of human mitochondrial disorders publication-title: Annu Rev Genet doi: 10.1146/annurev.ge.29.120195.001055 contributor: fullname: Larsson – volume: 31 start-page: 754 year: 1985 ident: 10.1086/303040_bib35 article-title: Determination of L-carnitine in serum, and implementation on the ABA-100 and CentrifiChem 600 publication-title: Clin Chem doi: 10.1093/clinchem/31.5.754 contributor: fullname: Rodriguez-Segade – volume: 16 start-page: 35 year: 1996 ident: 10.1086/303040_bib29 article-title: Short-term inhibition of the energy metabolism affects motility but not surface properties of sperm cells publication-title: Biosci Rep doi: 10.1007/BF01200999 contributor: fullname: Pascual – volume: 8 start-page: 1863 year: 1993 ident: 10.1086/303040_bib9 article-title: Mitochondrial Disease and Reduced Sperm Motility publication-title: Hum Reprod doi: 10.1093/oxfordjournals.humrep.a137950 contributor: fullname: Følgero – volume: 94 start-page: 1166 year: 1997 ident: 10.1086/303040_bib42 article-title: In vivo control of respiration by cytochrome c oxidase in wild-type and mitochondrial DNA mutation-carrying human cells publication-title: Proc Natl Acad Sci USA doi: 10.1073/pnas.94.4.1166 contributor: fullname: Villani – volume: 16 start-page: 403 year: 1995 ident: 10.1086/303040_bib8 article-title: Mitochondrial mutation associated with nonsyndromic deafness publication-title: Am J Otolaryngol doi: 10.1016/0196-0709(95)90078-0 contributor: fullname: Fischel-Ghodsian – volume: 383 start-page: 224 year: 1996 ident: 10.1086/303040_bib11 article-title: Mitochondria and male disease publication-title: Nature doi: 10.1038/383224a0 contributor: fullname: Frank – volume: 5 start-page: 963 year: 1996 ident: 10.1086/303040_bib13 article-title: Biochemical evidence for nuclear gene involvement in phenotype of non-syndromic deafness associated with mitochondrial 12S rRNA mutation publication-title: Hum Mol Genet doi: 10.1093/hmg/5.7.963 contributor: fullname: Guan – volume: 1 start-page: 32 year: 1995 ident: 10.1086/303040_bib21 article-title: Mitochondrial DNA mutations in multiple sclerosis publication-title: Mult Scler doi: 10.1177/135245859500100106 contributor: fullname: Kalman – volume: 29 start-page: 175 year: 1998 ident: 10.1086/303040_bib28 article-title: Characterization of the mitochondrial genome in childhood multiple sclerosis I. Optic neuritis and LHON mutations publication-title: Neuropediatrics doi: 10.1055/s-2007-973557 contributor: fullname: Ohlenbusch – volume: 6 start-page: 443 year: 1997 ident: 10.1086/303040_bib32 article-title: Molecular phenotype of a human lymphoblastoid cell-line homoplasmic for the np 7445 deafness-associated mitochondrial mutation publication-title: Hum Mol Genet doi: 10.1093/hmg/6.3.443 contributor: fullname: Reid – volume: 13 start-page: 1532 year: 1999 ident: 10.1086/303040_bib6 article-title: Mitochondrial DNA inherited variants are associated with successful aging and longevity in humans publication-title: Faseb J doi: 10.1096/fasebj.13.12.1532 contributor: fullname: De Benedictis – volume: 16 start-page: 93 year: 1997 ident: 10.1086/303040_bib20 article-title: Tissue-specific selection for different mtDNA genotypes in heteroplasmic mice publication-title: Nat Genet doi: 10.1038/ng0597-93 contributor: fullname: Jenuth – volume: 8 start-page: 95 year: 1994 ident: 10.1086/303040_bib30 article-title: Linkage of the gene for Wolfram syndrome to markers on the short arm of chromosome 4 publication-title: Nat Genet doi: 10.1038/ng0994-95 contributor: fullname: Polymeropoulos – volume: 57 start-page: 201 year: 1995 ident: 10.1086/303040_bib43 article-title: Mitochondrial DNA variation in human evolution, degenerative disease, and aging publication-title: Am J Hum Genet contributor: fullname: Wallace
SSID	ssj0011803
Score	2.2660635
Snippet	A variety of mtDNA mutations responsible for human diseases have been associated with molecular defects in the OXPHOS system. It has been proposed that mtDNA...
SourceID	pubmedcentral proquest crossref pubmed pascalfrancis elsevier
SourceType	Open Access Repository Aggregation Database Index Database Publisher
StartPage	682
SubjectTerms	Base Sequence Biological and medical sciences Birth control DNA, Mitochondrial - genetics European Continental Ancestry Group - genetics Extrachromosomal Inheritance - genetics Female Gene Frequency - genetics Gynecology. Andrology. Obstetrics Haplotypes - genetics Heterozygote Humans Infertility, Male - genetics Infertility, Male - pathology Male Medical sciences Mitochondria - enzymology Mitochondria - genetics Mitochondria - metabolism Mutation - genetics Oxidative Phosphorylation Phenotype Polymorphism, Genetic - genetics RNA, Transfer - genetics Sperm Motility - genetics Sperm Tail - physiology Spermatozoa - enzymology Spermatozoa - metabolism Spermatozoa - pathology Spermatozoa - physiology Sterility. Assisted procreation
Title	Human mtDNA Haplogroups Associated with High or Reduced Spermatozoa Motility
URI	https://dx.doi.org/10.1086/303040 https://www.ncbi.nlm.nih.gov/pubmed/10936107 https://search.proquest.com/docview/71760128 https://pubmed.ncbi.nlm.nih.gov/PMC1287528
Volume	67
hasFullText	1
inHoldings	1
isFullTextHit
isPrint
link	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1LT-MwEB5RJCSkFeKxQHn6wIVDqBvHSXpEPFTEQwhYiVvkOLYWaZtEND3Ar2cmTqDlcdlr4iTWzMTzjWf8DcBBKmRqhbGebyODAYrmXsoz6xke2JTowUWdaB_eRzeP8ekZ0eTI9ixMXbSv06ej_N_oKH_6W9dWliPda-vEerfXJ7imRtKPex3oIDZsQ_QmddCPuWgxL_r-aKqhkKA8YN37DeN4xA3RT87oV6nGKCLrelt8Bz4_11BOOaXzZVhq0CQ7drNegTmTr8KC6y_5sgZX9RY9G1WnN8dsqEripy4m5Zi1SjEZo41YRtUerHhmd0TkihfvS1qwq-K1UOy6qKh-9uU3_Dk_ezgZek37BE8Hwq88a-JUZlzqIDSBz60f2qhvtPQzZa0cBJoLkyEcU8qQHxtIiscQDmpinEFUI9ZhPi9yswmMGxsgTvC1HMSBknaQWiP7aZ9zLUMlRBf2WzkmpWPJSOrsdhwmTuhdOGzFmzS-3fnsBJfuL2N3Z-T_8UrqmBXS11p9JPgzUIZD5aaYjBOMTUPyuF3YcNqZmo3TeBeiGb29DyCa7dk7aH013XZjbVv__eQ2LLoD_FSZtgPz1fPE7EJnnE32EMRfXO7VBvwG6VzzwA
link.rule.ids	230,315,729,782,786,887,27933,27934,53800,53802
linkProvider	National Library of Medicine
linkToHtml	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3JTsMwEB2xCIGE2Jey-sCFQ6gbx0l6RCwqoq0Qi8QtchxbINEkoukBvh5PnEDLcuEaZ_WzPW88kzcARzHjsWZKO64OlHFQJHVimmhHUU_HKA_OykB75y7oP4bnFyiTw-t_YcqkfRk_n6Qvg5P0-anMrcwHslnniTVvemdmTQ24GzanYdbMV0prJ70KHrRCymrWa6x_MFZSiGEksKz-Zjx5wxyCv8zRYi6GppO0rW7xG_38nkU5ZpYul__5QSuwVPFQcmqbV2FKpWswZytTvq1Dt9zcJ4PivH9KOiJHZetslA9JDadKCG7hEswTIdkruUUJWHPwLselvsjeM0F6WYGZt28b8HB5cX_WcarCC470mFs4WoUxTyiXnq88l2rX10FLSe4mQmve9iRlKjFETgiFFrDN0ZMzRFKiVo3hQ2wTZtIsVdtAqNKeYRiu5O3QE1y3Y614K25RKrkvGGvAYd3_UW71NaIyLh76kQWrAcc1LFHFCqy1j8yi_-Pc_Qncvm6JtbZ8fFqNY2SmEcZGRKqy0TAyXq2PtroBWxbVsbexI6UBwQTenyegQPdki4G5FOquYN3595WHMN-573Wj7lX_ehcWrAwA5rftwUzxOlL7MD1MRgfl8P8AfM8IXw
linkToPdf	http://sdu.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3Pb9MwFH6iRZuQEDA2oIytPnDhkNaN4yQ9VmurorVVRUHiFjmOrVVak6hND-Wvxy9ORjvgAtfE-fnFft_Le_o-gI8x47FmSjuuDpRJUCR1YppoR1FPxygPzspC-2QZzL-HwxHK5DxYfZVN-zJeddL7dSdd3ZW9lfladus-se5idmPW1IC7YTdPdLcBT82cpW6dqFcFhF5IWc18DQMIDmyFGFYDSwc4k80b9hD8LSQ9z8XWvChtHS7-REEfd1IehKbxy_94qFfwouKjZGCHnMETlb6GE-tQuT-HafmTn6yL4XxAJiJHhetsl29JDatKCP7KJdgvQrIN-YJSsGbjMsclv8h-ZILMsgI7cPcX8G08-nozcSoDBkd6zC0crcKYJ5RLz1eeS7Xr66CnJHcToTXve5IylRhCJ4TCSNjnmNEZQilRs8bwIvYGmmmWqndAqNKeYRqu5P3QE1z3Y614L-5RKrkvGGtBu8Ygyq3ORlTWx0M_soC14FMNTVSxAxv1I7P4_zb26gi7X6dEzy0fr1ZjGZnphDUSkapst41MdutjzG7BW4vswd3Yr6UFwRHmDwNQqPt4j4G6FOyuoH3_z0e24XQxHEfTz_PbS3hm1QCwze0DNIvNTl1BY5vsrssZ8BPalwrf
openUrl	ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Human+mtDNA+Haplogroups+Associated+with+High+or+Reduced+Spermatozoa+Motility&rft.jtitle=American+journal+of+human+genetics&rft.au=Ruiz-Pesini%2C+Eduardo&rft.au=Lape%C3%B1a%2C+Ana-Cristina&rft.au=D%C3%ADez-S%C3%A1nchez%2C+Carmen&rft.au=P%C3%A9rez-Martos%2C+Acisclo&rft.date=2000-09-01&rft.pub=Elsevier+Inc&rft.issn=0002-9297&rft.eissn=1537-6605&rft.volume=67&rft.issue=3&rft.spage=682&rft.epage=696&rft_id=info:doi/10.1086%2F303040&rft.externalDocID=S0002929707632558
thumbnail_l	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0002-9297&client=summon
thumbnail_m	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0002-9297&client=summon
thumbnail_s	http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0002-9297&client=summon