Adjuvant therapy for endometrial cancer

• Published in: Journal of gynecologic oncology Vol. 25; no. 2; pp. 136 - 147
• Main Authors: Deleon, Maria C, Ammakkanavar, Natraj R, Matei, Daniela
• Format: Journal Article
• Language: English
• Published: Korea (South) Asian Society of Gynecologic Oncology; Korean Society of Gynecologic Oncology 01-04-2014; 대한부인종양학회
• Subjects: Review; 산부인과학; Early stage; Endometrial cancer; Adjuvant therapy; Locally advanced; Risk stratification
• ISSN: 2005-0380; 2005-0399
• DOI: 10.3802/jgo.2014.25.2.136

Endometrial cancer is a common gynecologic malignancy typically diagnosed at early stage and cured with surgery alone. Adjuvant therapy is tailored according to the risk of recurrence, estimated based on the International Federation of Gynecology and Obstetrics (FIGO) stage and other histological factors. The objective of this manuscript is to review the evidence guiding adjuvant therapy for early stage and locally advanced uterine cancer. For patients with early stage disease, minimizing toxicity, while preserving outstanding cure rates remains the major goal. For patients with locally advanced endometrial cancer optimal combined regimens are being defined. Risk stratification based on molecular traits is under development and may aid refine the current risk prediction model and permit personalized approaches for women with endometrial cancer.