Post-operative recovery after inguinal herniotomy in ex-premature infants: comparison between sevoflurane and spinal anaesthesia

• Published in: British journal of anaesthesia : BJA Vol. 86; no. 3; pp. 366 - 371
• Main Authors: Williams, J.M., Stoddart, P.A., Williams, S.A.R., Wolf, A.R.
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01-03-2001; Oxford University Press
• Subjects: Abdominal surgery. Urology. Gynecology. Obstetrics; anaesthesia, paediatric; anaesthetic techniques, subarachnoid; anaesthetics volatile, sevoflurane; Anesthesia; Anesthesia depending on patient's condition; Anesthesia depending on type of surgery; Anesthesia, Spinal; Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy; Anesthetics, Inhalation; Anesthetics, Local; Apnea - chemically induced; Biological and medical sciences; Bradycardia - chemically induced; Bupivacaine; Hernia, Inguinal - congenital; Hernia, Inguinal - surgery; Humans; Infant; Infant, Newborn; Infant, Premature; Infant, Premature, Diseases - surgery; Medical sciences; Methyl Ethers; Oxygen - blood; Partial Pressure; Postoperative Complications; Prospective Studies; Sevoflurane; Single-Blind Method; anaesthetics volatile, sevoflurane; anaesthetic techniques, subarachnoid; anaesthesia, paediatric; anaesthesia, paediatric; anaesthetics volatile, sevoflurane; anaesthetic techniques, subarachnoid; Human; Volatile compound; Postoperative; Premature; General anesthesia; Infant; Inguinal; Intrathecal administration; Hernia; Sevoflurane; Regional anesthesia; Newborn; General anesthetic; Abdominal disease; Surgery; Complication; Comparative study; Halogen Organic compounds
• ISSN: 0007-0912; 1471-6771
• DOI: 10.1093/bja/86.3.366

We prospectively studied the post-operative recovery profile of 28 ex-premature infants undergoing inguinal herniotomy. All infants had a post-conceptual age of less than 46 weeks at the time of surgery and were randomized to receive either sevoflurane (group 1, 14 patients) or spinal anaesthesia (group 2, 14 patients). All patients received supplemental caudal analgesia before skin incision. Cardiorespiratory function was continuously recorded in all patients before and after surgery. A blinded observer analysed each paired recording for predefined episodes of apnoea, hypoxaemia or bradycardia and the reports were used to compare the two groups. Spinal anaesthesia was attempted unsuccessfully in four patients in group 2. Five patients in group 1 demonstrated an ‘excess' number of episodes (median 4, range 3–12) of clinically silent post-operative cardiorespiratory complications. (‘Excess' in our study was defined as a 3-fold or greater increase in the number of post-operative episodes of bradycardia or apnoea relative to pre-operative occurrence). Three of these patients had pre-existing abnormal respiratory function and accounted for 80% of the episodes (26/32) of post-operative bradycardia and all five episodes of post-operative apnoea identified. All episodes of bradycardia and apnoea were temporally unrelated. None of the remaining patients in group 2 demonstrated an unacceptable number of post-operative cardiorespiratory complications. Our limited study suggests that general anaesthesia with an inhalational agent such as sevoflurane may induce or unmask abnormalities of cardiopulmonary function in predisposed infants. Spinal anaesthesia may be preferable but it is potentially stressful for the infant and associated with a clinically significant failure rate.