Action of silver nanoparticles towards biological systems: cytotoxicity evaluation using hen's egg test and inhibition of Streptococcus mutans biofilm formation

• Published in: International journal of antimicrobial agents Vol. 45; no. 2; pp. 183 - 187
• Main Authors: Freire, Priscila L.L, Stamford, Thayza C.M, Albuquerque, Allan J.R, Sampaio, Fabio C, Cavalcante, Horacinna M.M, Macedo, Rui O, Galembeck, André, Flores, Miguel A.P, Rosenblatt, Aronita
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-02-2015
• Subjects: Animals; Anti-Bacterial Agents - pharmacology; Antibacterial activity; Antifouling; Biofilms - drug effects; Chickens; Colloids; Dental caries; Female; HET-CAM or irritation delay; Infectious Disease; Metal Nanoparticles - chemistry; Silver - chemistry; Streptococcus mutans - drug effects; Dental caries; Antibacterial activity; Colloids; Antifouling; HET-CAM or irritation delay
• ISSN: 0924-8579; 1872-7913
• DOI: 10.1016/j.ijantimicag.2014.09.007

Highlights • The manuscript introduces new silver nanoparticle colloid products. • It focuses on the bactericidal effect and toxicity of AgNPs as the active compound against S. mutans. • This is an in vitro study using a cell flow system to simulate the oral environment to verify the inhibition of S. mutans biofilm formation by the novel products of AgNPs. • A new methodology is used to infer toxicity of compounds by HET-CAM. • The study indicates that use of AgNPs colloids is promising as anti-caries products.