Study of the participation of MMP-7, EMMPRIN and cyclophilin A in the pathogenesis of periodontal disease

• Published in: Archives of oral biology Vol. 72; pp. 172 - 178
• Main Authors: de Oliveira Nóbrega, Fernando José, de Oliveira, Denise Hélen Imaculada Pereira, Vasconcelos, Rodrigo Gadelha, Nonaka, Cassiano Francisco Weege, Queiroz, Lélia Maria Guedes
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01-12-2016
• Subjects: Advanced Basic Science; Basigin - metabolism; Chronic Periodontitis - metabolism; Chronic Periodontitis - pathology; Cyclophilin A; Cyclophilin A - metabolism; Dentistry; Disease Progression; Female; Gingival Crevicular Fluid - chemistry; Humans; Immunoenzyme Techniques; Inflammation; Male; Matrix metalloproteinase; Matrix Metalloproteinase 7 - metabolism; Periodontitis; Inflammation; Matrix metalloproteinase; Periodontitis; Cyclophilin A
• ISSN: 0003-9969; 1879-1506
• DOI: 10.1016/j.archoralbio.2016.08.032

Highlights • MMP-7 is involved in the destruction of periodontal tissue, levels are elevated in gingival tissue of patients with chronic periodontitis. • An increase in EMMPRIN levels in gingival crevicular fluid is associated with increased inflammation and, consequently, with the severity of periodontal disease. • CypA may be associated with the inflammatory responses and alveolar bone destruction in periodontitis. • The complexity of the mechanisms underlying the progression of periodontal disease.