The Age-dependent Elevation of miR-335-3p Leads to Reduced Cholesterol and Impaired Memory in Brain

[Display omitted] •MiR-335-3p is enriched in aged cultured astrocytes and hippocampal brain of aged mice.•MiR-335-3p reduces cellular cholesterol by suppressing HMGCS1 and HMGCR, key enzymes in cholesterol biosynthesis pathway.•MiR-335-3p deficiency leads to rescued PSD95 level and cognitive impairm...

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Bibliographic Details
Published in:	Neuroscience Vol. 390; pp. 160 - 173
Main Authors:	Raihan, Obayed, Brishti, Afrina, Molla, Md Rasel, Li, Wenbo, Zhang, Qilun, Xu, Peng, Khan, Muhammad Imran, Zhang, Juan, Liu, Qiang
Format:	Journal Article
Language:	English
Published:	United States Elsevier Ltd 15-10-2018
Subjects:	Aging Animals astrocytes Astrocytes - metabolism cholesterol Cholesterol - metabolism Coculture Techniques Disks Large Homolog 4 Protein - metabolism Gene Expression Regulation HEK293 Cells Hippocampus - metabolism Humans Male Memory Mice Mice, Inbred C57BL MicroRNAs - metabolism miRNA Neurons - metabolism Signal Transduction PSD95 memory HMGCS1 miRNA cholesterol HMGCR astrocytes aging GFAP
Online Access:	Get full text
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