Persistent organochlorinated pesticides and mechanisms of their toxicity

Highlights ► Diet is a major source of OCP exposure for the general population. ► OCPs exposure can induce enzymes for hormones and toxicants metabolisms. ► OCPs exposure are suspected to be associated to endocrine function disruption. ► Possible toxicity mechanisms are hormone disruption, oxidative...

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Bibliographic Details
Published in:	Toxicology (Amsterdam) Vol. 307; pp. 74 - 88
Main Authors:	Mrema, Ezra J, Rubino, Federico M, Brambilla, Gabri, Moretto, Angelo, Tsatsakis, Aristidis M, Colosio, Claudio
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 10-05-2013
Subjects:	adverse effects Adverse health effect air air pollution bioaccumulation breathing DDT (pesticide) DDT - toxicity dibenzofuran Emergency Endocrine Disruptors - toxicity endocrine system endosulfan Endosulfan - toxicity Environmental Exposure - adverse effects epigenetics food chain HCH (pesticide) hexachlorobenzene Hexachlorobenzene - toxicity Human exposure Humans Hydrocarbons, Chlorinated - toxicity hydrophobicity ingestion Lindane - toxicity long term effects mechanism of action Mechanisms of action metabolites Organochlorinated pesticides oxidation persistent organic pollutants Pesticides - toxicity polychlorinated biphenyls public health toxicity toxicology NO Cytosine Guanine base pair PCBs Mechanisms of action Organochlorinated pesticides HO superoxide radical TCDD polychlorinated dibenzofurans p, p′-DDD p, p′-DDE GABAA o, p′-DDD o, p′-DDE 1,1,1-trichloro-2-( o-chlorophenyl)-2-( p chlorophenyl)-ethane polychlorinated biphenyls PI3K DDT polychlorinated dibenzo-p-dioxins PCDFs 1,1-dichloro-2-( o-chlorophenyl)-2-( p-chlorophenyl)ethylene 1,1,1-trichloro-2,2-bis(p-chlorophenyl) ethane phosphatidylinositol 3-kinase o, p′-DDT O 2 beta-hexachlorocyclohexane HCB 1,1-dichloro-2, 2-bis (4-chlorophenyl)ethane PCDDs 2-OHE Human exposure dichlorodiphenyltrichloroethane 2,3,7,8-tetrachlorodibenzo-p-dioxin nitrogen oxide radical hydroxyl radical 1,1-dichloro-2,2-bis(p-chlorophenyl)-ethylene 1,1-dichloro-2-( o-chlorophenyl)-2-( p chlorophenyl)ethane gamma butyric acid type A Receptor 6 CpG hexachlorobenzene 16α-OHE 16α-hydroxyestrone β-HCH 2-hydroxyestrone p, p′-DDT Adverse health effect O2 p,p′-DDE o,p′-DDE o,p′-DDD p,p′-DDD o,p′-DDT p,p′-DDT
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