TLR5 Variants Are Associated with the Risk for COPD and NSCLC Development, Better Overall Survival of the NSCLC Patients and Increased Chemosensitivity in the H1299 Cell Line

Chronic obstructive pulmonary disease (COPD) is considered as the strongest independent risk factor for lung cancer (LC) development, suggesting an overlapping genetic background in both diseases. A common feature of both diseases is aberrant immunity in respiratory epithelia that is mainly regulate...

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Bibliographic Details
Published in:	Biomedicines Vol. 10; no. 9; p. 2240
Main Authors:	Baranašić, Jurica, Šutić, Maja, Catalano, Calogerina, Drpa, Gordana, Huhn, Stefanie, Majhen, Dragomira, Nestić, Davor, Kurtović, Matea, Rumora, Lada, Bosnar, Martina, Vukić Dugac, Andrea, Sokolović, Irena, Popovic-Grle, Sanja, Oršolić, Nada, Škrinjarić-Cincar, Sanda, Jakopović, Marko, Samaržija, Miroslav, Weber, Alexander N R, Försti, Asta, Knežević, Jelena
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 09-09-2022 MDPI
Subjects:	Activator protein 1 Alleles Association analysis Biomarkers Blood & organ donations Cell survival chemoresistance Chronic obstructive pulmonary disease Colorectal cancer COPD Cytokines Flagellin Genomes Genomics Immune response Inflammation Innate immunity Ligands Lung cancer Lung diseases NF-κB protein Non-small cell lung carcinoma NSCLC Obstructive lung disease Phosphorylation Receptor mechanisms Risk factors Single-nucleotide polymorphism SNP Software survival TLR5 TLR5 protein Toll-like receptors Transcription factors Transcriptomics United States > US Berlin Germany Germany Croatia chemoresistance NSCLC SNP TLR5 survival COPD
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