Human interleukin 3: effects on normal and leukemic cells

The effects of recombinant human interleukin 3 (IL3) on normal bone marrow cells and human leukemic cells were studied. In clonal assays, IL3 supported the growth of all colony types including megakaryocytes. Erythroid colonies were formed in the presence of IL3 and erythropoietin, but not in the ab...

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Bibliographic Details

Published in:	Growth factors (Chur, Switzerland) Vol. 1; no. 2; p. 101
Main Authors:	Barber, K E, Crosier, P S, Purdie, K J, Buchanan, J M, Cattermole, J A, Watson, J D, Gillis, S
Format:	Journal Article
Language:	English
Published:	England 1989
Subjects:	Blood Cells - drug effects Blood Cells - physiology Bone Marrow - drug effects Bone Marrow Cells Cell Division - physiology Cell Line Cells, Cultured Humans Interleukin-3 - genetics Interleukin-3 - physiology Leukemia - blood Recombinant Proteins - pharmacology RNA, Messenger - metabolism RNA, Neoplasm - metabolism Tumor Cells, Cultured
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