Bioelectrical Impedance Analysis of Oral Cavity Mucosa in Patients with Lichen Planus and Healthy Controls

• Published in: Dentistry journal Vol. 10; no. 7; p. 137
• Main Authors: Bacci, Christian, Cerrato, Alessia, Frigo, Anna Chiara, Cocco, Matteo, Zanette, Gastone
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 19-07-2022; MDPI
• Subjects: Bioelectricity; Buccal mucosa; cancer; diagnostic procedure; Electric currents; Electrodes; Gingiva; Impedance; Inflammation; Inflammatory diseases; Lichen planus; Mathematical analysis; Medical diagnosis; Medical equipment; Mouth; Oral cancer; Oral cavity; oral lesions; oral lichen planus; oral pathology; Palate; Patients; Phase shift; Reactance; Skin diseases; Statistical analysis; Tissues; Italy; cancer; diagnostic procedure; oral lesions; oral lichen planus; oral pathology; oral cancer
• DOI: 10.3390/dj10070137
• EISSN: 2304-6767

Objectives: Oral lichen planus (OLP) is an inflammatory disease. Bioelectrical impedance analysis (BIA) is a method for assessing tissue composition. Based on a combination of reactance and resistance data, a phase angle is calculated that may range from 90° to 0°, and that correlates with body cell mass. There is evidence to suggest that neoplastic tissue has a lower phase angle than normal tissue. The aim of the present experimental study was to establish whether OLP patients have a different tissue phase angle from healthy controls. Materials and Methods: Bioelectrical impedance measurements were obtained for the buccal mucosa, tongue, hard palate and upper anterior gums using an ad hoc device in a sample of 57 consecutive patients with OLP and 60 healthy controls, and their phase angles were calculated. Results: The mean resistance, reactance, and phase angle of the hard palate and gums were higher in the OLP group than in the controls, and the differences were statically significant. The resistance and reactance recorded for the adherent gingiva and hard palate were always higher in the OLP group (p = 0.044; p = 0.020; p = 0.054), and so was the phase angle for the adherent gingiva. No statistically significant differences emerged for the other areas of the oral cavity (p < 0.05). Conclusion: These findings confirm differences between the bioelectrical impedance of OLP lesions and that of healthy oral tissues. Clinical relevance: Bioelectrical impedance analysis could be useful in the diagnosis of OLP.