Efficacy assessment of self-assembled PLGA-PEG-PLGA nanoparticles: Correlation of nano-bio interface interactions, biodistribution, internalization and gene expression studies
[Display omitted] The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs) with various surface properties, composed of low and high Mw triblock PLGA-PEG-PLGA copolymers, applying rational quality and safety by design a...
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| Published in: | International journal of pharmaceutics Vol. 533; no. 2; pp. 389 - 401 |
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| Main Authors: | , , , , , , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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Elsevier B.V
30-11-2017
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| Abstract | [Display omitted]
The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs) with various surface properties, composed of low and high Mw triblock PLGA-PEG-PLGA copolymers, applying rational quality and safety by design approach. Therefore, along with the optimization of crucial physico-chemical properties and in order to evaluate the therapeutical potential and biocompatibility of prepared polymeric nanoparticles, analysis of nano-bio interactions, cell internalization, gene expression and biodistribution studies were performed.
The optimized formulations, one of low Mw and one composed of high Mw PLGA-PEG-PLGA copolymer, exhibited different characteristics in terms of surface properties, particle size, zeta potential, drug loading, protein adsorption and biodistribution, which may be attributed to the variations in nano–bio interface interactions due to different NP building blocks length and Mw. On the contrary to protein adsorption and biodistribution studies, both types of NPs exhibited similar results during cell internalization and gene expression studies performed in cell culture medium containing serum proteins.
This pool of useful data for internalization and efficacy as well as the notable advance in the circulation time of low Mw NPs may be further employed for shaping the potential of the designed nanocarriers. |
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| AbstractList | [Display omitted]
The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs) with various surface properties, composed of low and high Mw triblock PLGA-PEG-PLGA copolymers, applying rational quality and safety by design approach. Therefore, along with the optimization of crucial physico-chemical properties and in order to evaluate the therapeutical potential and biocompatibility of prepared polymeric nanoparticles, analysis of nano-bio interactions, cell internalization, gene expression and biodistribution studies were performed.
The optimized formulations, one of low Mw and one composed of high Mw PLGA-PEG-PLGA copolymer, exhibited different characteristics in terms of surface properties, particle size, zeta potential, drug loading, protein adsorption and biodistribution, which may be attributed to the variations in nano–bio interface interactions due to different NP building blocks length and Mw. On the contrary to protein adsorption and biodistribution studies, both types of NPs exhibited similar results during cell internalization and gene expression studies performed in cell culture medium containing serum proteins.
This pool of useful data for internalization and efficacy as well as the notable advance in the circulation time of low Mw NPs may be further employed for shaping the potential of the designed nanocarriers. The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs) with various surface properties, composed of low and high Mw triblock PLGA-PEG-PLGA copolymers, applying rational quality and safety by design approach. Therefore, along with the optimization of crucial physico-chemical properties and in order to evaluate the therapeutical potential and biocompatibility of prepared polymeric nanoparticles, analysis of nano-bio interactions, cell internalization, gene expression and biodistribution studies were performed. The optimized formulations, one of low Mw and one composed of high Mw PLGA-PEG-PLGA copolymer, exhibited different characteristics in terms of surface properties, particle size, zeta potential, drug loading, protein adsorption and biodistribution, which may be attributed to the variations in nano-bio interface interactions due to different NP building blocks length and Mw. On the contrary to protein adsorption and biodistribution studies, both types of NPs exhibited similar results during cell internalization and gene expression studies performed in cell culture medium containing serum proteins. This pool of useful data for internalization and efficacy as well as the notable advance in the circulation time of low Mw NPs may be further employed for shaping the potential of the designed nanocarriers. |
| Author | Dimovski, Aleksandar Monopoli, Marco P. Szczupak, Boguslaw Petruševski, Gjorgji Dimchevska, Simona Hristov, Delyan R. Koliqi, Rozafa Geskovski, Nikola Goracinova, Katerina Gomez Vallejo, Vanessa Llop, Jordi Ugarkovic, Sonja Matevska-Geskovska, Nadica Sebastian, Eneko San |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28552798$$D View this record in MEDLINE/PubMed |
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| Keywords | 7-Ethyl-10-hydroxycamptotecin (SN-38) PLGA-PEG-PLGA/PEO-PPO-PEO Polymeric nanoparticles Nanoprecipitation Nano–bio interface interactions Gene expression |
| Language | English |
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The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs)... The aim of our study was to develop and compare the biological performance of two types of biodegradable SN-38 loaded nanoparticles (NPs) with various surface... |
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| SubjectTerms | 7-Ethyl-10-hydroxycamptotecin (SN-38) Adsorption Animals Antineoplastic Agents, Phytogenic - administration & dosage Antineoplastic Agents, Phytogenic - chemistry Antineoplastic Agents, Phytogenic - pharmacokinetics Camptothecin - administration & dosage Camptothecin - analogs & derivatives Camptothecin - chemistry Camptothecin - pharmacokinetics Cell Cycle Proteins - genetics Cell Line, Tumor Fibroblast Growth Factor 3 - genetics Gene expression Gene Expression Regulation, Neoplastic - drug effects Histones - genetics Humans Irinotecan Molecular Weight Muscle Proteins - genetics Nanoparticles - administration & dosage Nanoparticles - chemistry Nanoprecipitation Nano–bio interface interactions Nerve Tissue Proteins - genetics Particle Size PLGA-PEG-PLGA/PEO-PPO-PEO Polyethylene Glycols - administration & dosage Polyethylene Glycols - chemistry Polyethylene Glycols - pharmacokinetics Polyglactin 910 - administration & dosage Polyglactin 910 - chemistry Polyglactin 910 - pharmacokinetics Polymeric nanoparticles Rats, Wistar Serum Albumin, Bovine - chemistry Surface Properties Tissue Distribution Ubiquitins - genetics |
| Title | Efficacy assessment of self-assembled PLGA-PEG-PLGA nanoparticles: Correlation of nano-bio interface interactions, biodistribution, internalization and gene expression studies |
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