Intestinal absorption of black chokeberry cyanidin 3-glycosides is promoted by capsaicin and capsiate in a rat ligated small intestinal loop model

• Published in: Food chemistry Vol. 277; pp. 323 - 326
• Main Authors: Takahashi, Azusa, Sakaguchi, Hirohide, Higuchi, Ohki, Suzuki, Takashi, Chiji, Hideyuki
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 30-03-2019
• Subjects: Animals; Anthocyanins - pharmacokinetics; Black chokeberry; Capsaicin; Capsaicin - analogs & derivatives; Capsaicin - pharmacokinetics; Capsiate; Fruit - chemistry; Glycosides - pharmacokinetics; Intestinal absorption; Intestinal Absorption - drug effects; Intestine, Small - drug effects; Intestine, Small - metabolism; Male; Photinia - chemistry; Plant Extracts - pharmacokinetics; Rats; Rats, Sprague-Dawley; Intestinal absorption; Black chokeberry; Capsiate; Capsaicin
• ISSN: 0308-8146; 1873-7072
• DOI: 10.1016/j.foodchem.2018.10.094

•The serum concentrations of anthocyanin were increased by capsaicin or capsiate.•The intestinal absorption of black chokeberry was lower than that of haskap.•The capsaicin and capsiate may open tight junctions in the rat small intestine.
Recent studies have shown that aronia (black chokeberry) and haskap fruits (contain anthocyanins) have beneficial health effects in animals and humans. However, some reports have shown that anthocyanin is poorly absorbed in the small intestine. In this study, we compared the intestinal absorption of aronia and haskap anthocyanins by using rats with a ligated small intestinal loop and cannulated portal vein.
Our results clearly showed that the intestinal absorption of aronia anthocyanins was significantly lower than that of haskap anthocyanins, suggesting that the intestinal absorption of anthocyanins is influenced by the glycoside type (galactoside or glucoside).
In addition, we also examined the effects of capsaicin and capsiate on intestinal anthocyanin absorption. The amount of aronia anthocyanins in portal blood was much higher when they were co-administered with capsaicin or capsiate. Our study is the first to show that the intestinal absorption of aronia anthocyanins is promoted by capsaicin and capsiate.