MRONJ Treatment Strategies: A Systematic Review and Two Case Reports

• Published in: Applied sciences Vol. 13; no. 7; p. 4370
• Main Authors: Inchingolo, Angelo Michele, Malcangi, Giuseppina, Ferrara, Irene, Patano, Assunta, Viapiano, Fabio, Netti, Anna, Azzollini, Daniela, Ciocia, Anna Maria, de Ruvo, Elisabetta, Campanelli, Merigrazia, Avantario, Pasquale, Mancini, Antonio, Inchingolo, Francesco, Isacco, Ciro Gargiulo, Corriero, Alberto, Inchingolo, Alessio Danilo, Dipalma, Gianna
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01-03-2023
• Subjects: Angiogenesis; Antimitotic agents; Antineoplastic agents; Apoptosis; Bisphosphonates; Bone marrow; Cancer therapies; Case reports; Clinical trials; concentrated growth factor; Denosumab; Disease; Disodium pamidronate; DRONJ; Drug dosages; Fluorescence; Hyaluronic acid; Hydroxyapatite; Infections; Invasiveness; Jaw; Ligands; Medical research; Medicine, Experimental; MRONJ; Necrosis; Nonsteroidal anti-inflammatory drugs; osteonecrosis; Pain; Patients; Pharmaceutical industry; platelet-rich plasma; Qualitative analysis; Radiation; Side effects; Surgery; Surgical equipment; Tiludronate; Trauma; Vascular endothelial growth factor
• ISSN: 2076-3417; 2076-3417
• DOI: 10.3390/app13074370

MRONJ is a serious drug-related side effect that is most common in people using antiresorptive and/or angiogenic medications. Therapy options for this condition include conservative treatments, surgical procedures with varied degrees of invasiveness, and adjuvant therapies. The aim of the present study is to identify the most successful and promising therapy alternatives available to clinicians. PubMed, Cochrane, Scopus, Web of Science, and Embase were searched for works on our topic published between 8 January 2006 and 8 January 2023. The search was restricted to randomized clinical trials, retrospective studies, clinical studies, and case series involving human subjects with at least five cases and no age restriction on participants. A total of 2657 was found. After the selection process, the review included 32 publications for qualitative analysis. Although conservative treatments (pharmacological, laser, and minimally invasive surgery) are effective in the early stages of MRONJs or as a supplement to traditional surgical resection therapy, most studies emphasize the importance of surgical treatment for the resolution or downstaging of advanced lesions. Fluorescence-guided surgery, PRP, PRF, CGF, piezosurgery, VEGF, hyaluronic acid, and ozone therapy all show significant potential for improving treatment outcomes.