Exacerbation of Damage and Altered NF-kappa B Activation in Mice Lacking Tumor Necrosis Factor Receptors after Traumatic Brain Injury

Tumor necrosis factor α (TNFα) is widely expressed in both neurons and glia and has been shown to be upregulated after traumatic brain injury (TBI). TNFα receptor activation results in activation of the transcription factor nuclear factor κB (NF-κB), which may serve an antiapoptotic role via the ind...

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Bibliographic Details
Published in:The Journal of neuroscience Vol. 19; no. 15; pp. 6248 - 6256
Main Authors: Sullivan, Patrick G, Bruce-Keller, Annadora J, Rabchevsky, Alexander G, Christakos, Sylivia, Clair, Daret K. St, Mattson, Mark P, Scheff, Stephen W
Format: Journal Article
Language:English
Published: Soc Neuroscience 01-08-1999
Society for Neuroscience
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