High Prevalence of Celiac Disease in Apparently Healthy Blood Donors Suggests a High Prevalence of Undiagnosed Celiac Disease in the Dutch Population

Background: In the last few years the prevalence of celiac disease (CD) seems to have increased. It is clear that subclinical and silent CD exist in a large subgroup of the celiac population. Methods: The aim of this study was to evaluate the prevalence of CD in an apparently healthy population. Blo...

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Bibliographic Details
Published in:	Scandinavian journal of gastroenterology Vol. 34; no. 3; pp. 276 - 279
Main Authors:	ROSTAMI, K, MULDER, C. J. J, WERRE, J. M, VAN BEUKELEN, F. R, KERCKHAERT, J, CRUSIUS, J. B. A, PENA, A. S, WILLEKENS, F. L. A, MEIJER, J. W. R
Format:	Journal Article
Language:	English
Published:	Copenhagen Informa UK Ltd 1999 Oslo Taylor & Francis Stockholm Scandinavian University Press
Subjects:	Adult Biological and medical sciences Biopsy, Needle Blood Donors - statistics & numerical data Celiac Disease - diagnosis Celiac Disease - epidemiology Gastroenterology. Liver. Pancreas. Abdomen HLA-DQ Antigens - analysis Humans Immunoglobulin A - analysis Jejunum - pathology Male Medical sciences Middle Aged Netherlands - epidemiology Other diseases. Semiology Prevalence Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Netherlands Europe Human Immunopathology Allergy IgA Antibody Asymptomatic Coeliac disease Medical screening Epidemiology Specificity Histopathology Intestinal malabsorption Endomysium Digestive diseases Intestinal disease Gluten Blood donor
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Summary:	Background: In the last few years the prevalence of celiac disease (CD) seems to have increased. It is clear that subclinical and silent CD exist in a large subgroup of the celiac population. Methods: The aim of this study was to evaluate the prevalence of CD in an apparently healthy population. Blood samples were obtained from 1000 apparently healthy blood donors at Arnhem and Nijmegen Blood Donation Centers from January 1997 through April 1998. Sera from 660 blood donors were assayed for total IgA. By means of immunofluorescence, antibodies, including those to endomysium (EMA), were determined. Serum immunoglobulin levels (IgA) were assayed by means of nephelometry. All donors who had positive serology for EMA underwent small-intestinal biopsy. Results
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0036-5521 1502-7708
DOI:	10.1080/00365529950173681