A 1,1′-biuracil from Epidermidibacterium keratini EPI-7 shows anti-aging effects on human dermal fibroblasts

• Published in: Applied biological chemistry Vol. 62; no. 1; pp. 1 - 6
• Main Authors: Lee, Yeong-Geun, Lee, Dong-Geol, Gwag, Jung Eun, Kim, Misun, Kim, Minji, Kim, Hyoung-Geun, Ko, Jung-Hwan, Yeo, Hyeonju, Kang, Seunghyun, Baek, Nam-In
• Format: Journal Article
• Language: English
• Published: Singapore Springer Singapore 18-03-2019; SpringerOpen; 한국응용생명화학회
• Subjects: 1,1′-Biuracil; Applied Microbiology; Biological Techniques; Bioorganic Chemistry; Chemistry; Chemistry and Materials Science; Epidermidibacterium keratini EPI-7; Human skin; Keratinocyte; Skin bacteria; 농학; EPI-7; Keratinocyte; Human skin; Skin bacteria; 1,1′-Biuracil
• ISSN: 2468-0834; 2468-0842
• DOI: 10.1186/s13765-019-0421-9

Our previous study we isolated novel bacterial stain,
Epidermidibacterium keratini
, called EPI-7
T
from skin samples. Repeated column separation yielded one new pyrimidine compound, 1,1′-biuracil, from EPI-7
T
culture solutions grown in R2A medium. Its chemical structure was determined based on spectroscopic data, IR, FAB/MS, and NMR. And 1,1′-biuracil and EPI-7
T
culture solutions showed regulating effects of anti-aging associated mRNA expressions in UV-irradiated fibroblasts without toxicity in Hs68 cells. These results demonstrates the cosmetic potential of 1,1′-biuracil and EPI-7
T
as anti-aging agents.