CLDN14 is epigenetically silenced by EZH2-mediated H3K27ME3 and is a novel prognostic biomarker in hepatocellular carcinoma

Trimethylation of lysine 27 on histone H3 (H3K27ME3) is a transcription-suppressive histone mark mediated by enhancer of zeste homolog 2 (EZH2). We have previously suggested that EZH2-mediated H3K27ME3 plays a critical oncogenic role in human hepatocellular carcinoma (HCC) aggressiveness. However, t...

Full description

Saved in:

Bibliographic Details
Published in:	Carcinogenesis (New York) Vol. 37; no. 6; pp. 557 - 566
Main Authors:	Li, Chang-Peng, Cai, Mu-Yan, Jiang, Li-Juan, Mai, Shi-Juan, Chen, Jie-Wei, Wang, Feng-Wei, Liao, Yi-Ji, Chen, Wen-Hui, Jin, Xiao-Han, Pei, Xiao-Qing, Guan, Xin-Yuan, Zeng, Mu-Sheng, Xie, Dan
Format:	Journal Article
Language:	English
Published:	England 01-06-2016
Subjects:	beta Catenin - metabolism Biomarkers, Tumor - genetics Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - mortality Carcinoma, Hepatocellular - pathology Cell Line, Tumor Claudins - genetics Claudins - metabolism Disease-Free Survival Enhancer of Zeste Homolog 2 Protein - genetics Enhancer of Zeste Homolog 2 Protein - metabolism Epigenesis, Genetic Gene Expression Regulation, Neoplastic Gene Silencing Humans Kaplan-Meier Estimate Liver Neoplasms - genetics Liver Neoplasms - mortality Liver Neoplasms - pathology Methylation Prognosis Wnt Proteins - genetics Wnt Proteins - metabolism
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!