Brook/Elimination/Aldol Reaction Sequence for the Direct One-Pot Preparation of Difluorinated Aldols from (Trifluoromethyl)trimethylsilane and Acylsilanes

A methodology allowing the one‐pot preparation of difluorinated aldols directly from Ruppert–Prakash reagent, acyltrimethylsilanes and aldehydes is reported. The process, initiated by a catalytic amount of an ammonium salt, involves the addition of (trifluoromethyl)trimethylsilane to the acylsilane,...

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Bibliographic Details

Published in:	Advanced synthesis & catalysis Vol. 358; no. 4; pp. 526 - 531
Main Authors:	Decostanzi, Mélanie, Godemert, Jérémy, Oudeyer, Sylvain, Levacher, Vincent, Campagne, Jean-Marc, Leclerc, Eric
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 18-02-2016 WILEY‐VCH Verlag Wiley-VCH Verlag
Subjects:	Aldehydes aldol reaction Anions Asymmetry Brook rearrangement Catalysis Chemical reactions Chemical Sciences Fluorides fluorine organocatalysis Reagents Synthesis
Online Access:	Get full text
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