Glandular hamartoma of the larynx: Report of a case

Abstract Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly rising respiratory distress, stridor, changes in voice, eating and activity levels. Management consists in local mass excision with a go...

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Published in:	Auris, nasus, larynx Vol. 35; no. 1; pp. 149 - 151
Main Authors:	Leoncini, Giuseppe, Maio, Vincenza, Mirabile, Lorenzo, Baggi, Roberto, Franchi, Alessandro
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ireland Ltd 01-03-2008
Subjects:	Airway Obstruction - etiology Hamartoma Hamartoma - congenital Hamartoma - pathology Hamartoma - surgery Humans Infant Laryngeal Neoplasms - congenital Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Laryngoscopy Larynx Larynx - pathology Laser Therapy Microsurgery Otolaryngology Larynx Hamartoma
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Abstract	Abstract Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly rising respiratory distress, stridor, changes in voice, eating and activity levels. Management consists in local mass excision with a good functional result and prognosis. Recurrences are usually associated with incomplete removal. We present a 3-month-old infant with a history of stridor and respiratory distress caused by a firm 0.4 cm wide and 1.4 cm long mass arising in the supraglottic region and detected with endoscopic approach. The lesion was excised endoscopically with an uneventful postoperative course and an excellent long-term prognosis. Histopathologically the lesion consisted of mature tissues with abnormal growth and disorganized architecture, chiefly composed of mature glandular structures, smooth muscular fibers, mature fat, surrounded by fibrous stroma and covered by typical squamous epithelium. The aim of our report is to underline how this condition must be considered by physicians, paediatricians and anaesthetists as an important cause of airway obstruction.
AbstractList	Abstract Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly rising respiratory distress, stridor, changes in voice, eating and activity levels. Management consists in local mass excision with a good functional result and prognosis. Recurrences are usually associated with incomplete removal. We present a 3-month-old infant with a history of stridor and respiratory distress caused by a firm 0.4 cm wide and 1.4 cm long mass arising in the supraglottic region and detected with endoscopic approach. The lesion was excised endoscopically with an uneventful postoperative course and an excellent long-term prognosis. Histopathologically the lesion consisted of mature tissues with abnormal growth and disorganized architecture, chiefly composed of mature glandular structures, smooth muscular fibers, mature fat, surrounded by fibrous stroma and covered by typical squamous epithelium. The aim of our report is to underline how this condition must be considered by physicians, paediatricians and anaesthetists as an important cause of airway obstruction. Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly rising respiratory distress, stridor, changes in voice, eating and activity levels. Management consists in local mass excision with a good functional result and prognosis. Recurrences are usually associated with incomplete removal. We present a 3-month-old infant with a history of stridor and respiratory distress caused by a firm 0.4cm wide and 1.4cm long mass arising in the supraglottic region and detected with endoscopic approach. The lesion was excised endoscopically with an uneventful postoperative course and an excellent long-term prognosis. Histopathologically the lesion consisted of mature tissues with abnormal growth and disorganized architecture, chiefly composed of mature glandular structures, smooth muscular fibers, mature fat, surrounded by fibrous stroma and covered by typical squamous epithelium. The aim of our report is to underline how this condition must be considered by physicians, paediatricians and anaesthetists as an important cause of airway obstruction. Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly rising respiratory distress, stridor, changes in voice, eating and activity levels. Management consists in local mass excision with a good functional result and prognosis. Recurrences are usually associated with incomplete removal. We present a 3-month-old infant with a history of stridor and respiratory distress caused by a firm 0.4 cm wide and 1.4 cm long mass arising in the supraglottic region and detected with endoscopic approach. The lesion was excised endoscopically with an uneventful postoperative course and an excellent long-term prognosis. Histopathologically the lesion consisted of mature tissues with abnormal growth and disorganized architecture, chiefly composed of mature glandular structures, smooth muscular fibers, mature fat, surrounded by fibrous stroma and covered by typical squamous epithelium. The aim of our report is to underline how this condition must be considered by physicians, paediatricians and anaesthetists as an important cause of airway obstruction.
Author	Mirabile, Lorenzo Baggi, Roberto Leoncini, Giuseppe Franchi, Alessandro Maio, Vincenza
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Cites_doi	10.1017/S0022215100130130 10.1001/archotol.131.3.259 10.1177/000348949810700314 10.1177/000348940311201003 10.1016/S0165-5876(99)00231-1 10.1177/000348949510400201 10.1016/S0165-5876(02)00150-7 10.1017/S0022215100136746 10.1016/j.ijporl.2004.07.005
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References_xml	– volume: 14 start-page: 305 year: 1995 end-page: 308 ident: bib2 article-title: Hamartoma of the larynx publication-title: J Otolaryngol contributor: fullname: Birt – volume: 104 start-page: 87 year: 1995 end-page: 89 ident: bib3 article-title: Laryngeal hamartoma: a rare congenital abnormality publication-title: Ann Otol Rhinol Layngol contributor: fullname: Arnold – volume: 50 start-page: 145 year: 1999 end-page: 149 ident: bib6 article-title: Laryngeal hamartoma: surgical management publication-title: Int J Pediatr Otorhinolaryngol contributor: fullname: Chevenova – start-page: 337 year: 1993 end-page: 347 ident: bib1 article-title: Blastoma, hamartoma and teratoma publication-title: Neoplasms of the larynx contributor: fullname: Ferlito – volume: 68 start-page: 1551 year: 2004 end-page: 1555 ident: bib12 article-title: Laryngeal chondroma: a rare neck tumor in pediatric age publication-title: Int J Pediatr Otorhinolaryngol contributor: fullname: Unal – volume: 131 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Snippet	Abstract Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include... Glandular hamartoma is an extremely rare congenital malformation of the larynx. Presenting symptoms result from airways obstruction and may include slowly...
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SubjectTerms	Airway Obstruction - etiology Hamartoma Hamartoma - congenital Hamartoma - pathology Hamartoma - surgery Humans Infant Laryngeal Neoplasms - congenital Laryngeal Neoplasms - pathology Laryngeal Neoplasms - surgery Laryngoscopy Larynx Larynx - pathology Laser Therapy Microsurgery Otolaryngology
Title	Glandular hamartoma of the larynx: Report of a case
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