Effects of Flagellin on the Functions of Follicle-Associated Epithelium

Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicleassociated epithelium (FAE) specialized for the uptake of a...

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Published in:	The Journal of infectious diseases Vol. 198; no. 6; pp. 907 - 910
Main Authors:	Chabot, Sophie M., Shawi, May, Eaves-Pyles, Tonyia, Neutra, Marian R.
Format:	Journal Article
Language:	English
Published:	Oxford The University of Chicago Press 15-09-2008 University of Chicago Press Oxford University Press
Subjects:	Agonists Animals Antigens Bacteria Biological and medical sciences Chemokines Dendritic cells Epithelial cells Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - physiology Epithelium Female Flagellin - genetics Flagellin - pharmacology Fundamental and applied biological sciences. Psychology Immunity, Mucosal Infectious diseases Matrix Metalloproteinases - metabolism Medical sciences Mice Mice, Inbred BALB C Microbiology Peyers patches Polymerase Chain Reaction Recombinant Proteins - pharmacology Salmonella - physiology Salmonella dublin T lymphocytes Toll like receptors Vaccination Infection Flagellin Microbiology Epithelium
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Abstract	Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicleassociated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase—dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.
AbstractList	Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicleassociated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase—dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa. Bacterial flagellin activates innate immune responses by signaling through Toll-like receptor 5 and is a potential vaccine adjuvant. Mucosal lymphoid follicles, inductive sites for adaptive mucosal immune responses, are covered by a follicle-associated epithelium (FAE) specialized for the uptake of antigens. This study demonstrates that mucosal application of Salmonella dublin flagellin enhanced transepithelial transport of microparticles by the FAE of mouse Peyer's patches in vivo. Flagellin also induced rapid, matrix metalloproteinase-dependent migration of subepithelial dendritic cells (DCs) into the FAE, better positioning DCs for antigen capture. These innate responses to flagellin enhance FAE functions and may promote adaptive immune responses in the mucosa.
Author	Eaves-Pyles, Tonyia Chabot, Sophie M. Neutra, Marian R. Shawi, May
Author_xml	– sequence: 1 givenname: Sophie M. surname: Chabot fullname: Chabot, Sophie M. organization: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts – sequence: 2 givenname: May surname: Shawi fullname: Shawi, May organization: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts – sequence: 3 givenname: Tonyia surname: Eaves-Pyles fullname: Eaves-Pyles, Tonyia organization: Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas – sequence: 4 givenname: Marian R. surname: Neutra fullname: Neutra, Marian R. email: marian.neutra@childrens.harvard.edu organization: Department of Pediatrics, Harvard Medical School, Boston, Massachusetts
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SubjectTerms	Agonists Animals Antigens Bacteria Biological and medical sciences Chemokines Dendritic cells Epithelial cells Epithelial Cells - drug effects Epithelial Cells - immunology Epithelial Cells - physiology Epithelium Female Flagellin - genetics Flagellin - pharmacology Fundamental and applied biological sciences. Psychology Immunity, Mucosal Infectious diseases Matrix Metalloproteinases - metabolism Medical sciences Mice Mice, Inbred BALB C Microbiology Peyers patches Polymerase Chain Reaction Recombinant Proteins - pharmacology Salmonella - physiology Salmonella dublin T lymphocytes Toll like receptors Vaccination
Title	Effects of Flagellin on the Functions of Follicle-Associated Epithelium
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