Reversible non-oliguric impairment of renal function during azapropazone treatment

An impairment of the renal function was observed in three patients who received azapropazone for various rheumatic disorders with simultaneous hyperuricaemia. A distinct increase in serum creatinine occurred in all patients. In one case the renal biopsy suggested a hypersensitivity reaction with a c...

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Bibliographic Details
Published in:	Scandinavian journal of rheumatology Vol. 15; no. 1; p. 23
Main Authors:	Sipilä, R, Skrifvars, B, Törnroth, T
Format:	Journal Article
Language:	English
Published:	England 1986
Subjects:	Acute Disease Apazone - adverse effects Apazone - therapeutic use Arthritis - drug therapy Creatinine - blood Female Humans Kidney Diseases - chemically induced Male Middle Aged Nephritis, Interstitial - chemically induced Triazines - adverse effects Urea - blood
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Summary:	An impairment of the renal function was observed in three patients who received azapropazone for various rheumatic disorders with simultaneous hyperuricaemia. A distinct increase in serum creatinine occurred in all patients. In one case the renal biopsy suggested a hypersensitivity reaction with a consequent acute tubulo-interstitial nephritis as the mechanism of the impaired renal function. The renal insufficiency was reversible in all cases after the withdrawal of azapropazone.
ISSN:	0300-9742
DOI:	10.3109/03009748609092664