Helicobacter pylori Prevalence in Diabetes Mellitus Patients with Dyspeptic Symptoms and its Relationship to Glycemic Control and Late Complications

• Published in: Digestive diseases and sciences Vol. 53; no. 10; pp. 2646 - 2649
• Main Authors: Demir, Mehmet, Gokturk, Huseyin Savas, Ozturk, Nevin Akcaer, Kulaksizoglu, Mustafa, Serin, Ender, Yilmaz, Ugur
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01-10-2008; Springer; Springer Nature B.V
• Subjects: Adult; Bacterial diseases; Bacterial diseases of the digestive system and abdomen; Biochemistry; Biological and medical sciences; Blood Glucose - metabolism; Case-Control Studies; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - metabolism; Diabetes Mellitus, Type 2 - microbiology; Diabetes. Impaired glucose tolerance; Diabetic Nephropathies - microbiology; Diabetic Neuropathies - microbiology; Diabetic Retinopathy - microbiology; Dyspepsia - metabolism; Dyspepsia - microbiology; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Feeding. Feeding behavior; Female; Fundamental and applied biological sciences. Psychology; Gastroenterology; Glycated Hemoglobin A - metabolism; Helicobacter Infections - epidemiology; Helicobacter Infections - metabolism; Helicobacter pylori; Hepatology; Human bacterial diseases; Humans; Infectious diseases; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Oncology; Original Paper; Prevalence; Transplant Surgery; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Complication; Diabetes mellitus; Prevalence; Endocrinopathy; Human; Spirillales; Dyspepsia; Spirillaceae; Metabolic diseases; Epidemiology; Prevalence, Complication; Symptomatology; Helicobacter pylori; Helicobacter pylori, Diabetes mellitus; Gastroenterology; Bacteria; Digestive diseases
• ISSN: 0163-2116; 1573-2568
• DOI: 10.1007/s10620-007-0185-7

Background
There are contradictory reports on
Helicobacter pylori
prevalence and its relationship to late complications of diabetes mellitus (DM). The aim of this study was to determine the prevalence of
H. pylori
infection in type 2 DM patients and to evaluate the relationship between
H. pylori
infection and the glycemic control, late complications.
Material and Method
A total of 141 type 2 DM patients and 142 nondiabetic subjects with upper gastrointestinal symptoms were enrolled in the study. All patients underwent upper gastrointestinal endoscopy with biopsy specimens obtained from gastric antrum and corpus.
H. pylori
status was evaluated in each patient by both the rapid urease test and histopathological examination. Plasma glucose, HbA1c, microalbuminuria in 24 h collected urine, electroneuromyography, and fundoscopic examinations were performed in all subjects.
Results
The prevalence of
H. pylori
infection was 61.7% and 58.5%, respectively, among type 2 diabetic patients and nondiabetic controls and was not statistically significant (
P
 = 0.577). The duration of diabetes, fasting blood glucose and haemoglobin A1c levels, nephropathy and retinopathy prevalence did not differ significantly between the two groups (diabetics versus nondiabetics). There was no late complication in 60.3% of the type 2 diabetic patients as compared to at least one late complication in the remainders. A statistically significant correlation was found between
H. pylori
infection and the presence of neuropathy (
P
 = 0.021).
Conclusions
The prevalence of
H. pylori
infection did not differ significantly between the diabetic patients and nondiabetic controls. Interestingly, diabetics with
H. pylori
infection had a higher incidence of neuropathy, although there was no association between the duration and regulation of diabetes, retinopathy, nephropathy and
H. pylori
status.