Short peptide nucleic acids (PNA) inhibit hepatitis C virus internal ribosome entry site (IRES) dependent translation in vitro

The internal ribosome entry site (IRES) of hepatitis C virus (HCV) which governs the initiation of protein synthesis from viral RNA represents an ideal target for antisense approaches. Using an original bicistronic plasmid, we first established that sequence and translational activity of HCV IRESs c...

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Bibliographic Details
Published in:	Antiviral research Vol. 80; no. 3; pp. 280 - 287
Main Authors:	Alotte, Christine, Martin, Amaury, Caldarelli, Sergio A., Di Giorgio, Audrey, Condom, Roger, Zoulim, Fabien, Durantel, David, Hantz, Olivier
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier B.V 01-12-2008 Elsevier
Subjects:	5' Untranslated Regions Animals Antibiotics. Antiinfectious agents. Antiparasitic agents Antisense Antiviral agents Base Sequence Biological and medical sciences Cell Line DNA, Antisense - chemistry DNA, Antisense - genetics DNA, Antisense - pharmacology Down-Regulation - drug effects Hepacivirus - chemistry Hepacivirus - drug effects Hepacivirus - genetics Hepacivirus - metabolism Hepatitis C - drug therapy Hepatitis C - virology Hepatitis C virus Human viral diseases Humans Infectious diseases IRES JFH1 strain Medical sciences Molecular Sequence Data Peptide nucleic acid Peptide Nucleic Acids - chemistry Peptide Nucleic Acids - genetics Peptide Nucleic Acids - pharmacology Pharmacology. Drug treatments PNA Protein Biosynthesis - drug effects Rabbits Reticulocytes - metabolism Ribosomes - drug effects Ribosomes - genetics Ribosomes - metabolism Viral diseases Viral hepatitis Antisense PNA Peptide nucleic acid Hepatitis C virus IRES JFH1 strain Internal ribosome entry site Ribosome In vitro translation Targeting Nucleotide sequence Hepatic disease Research and development Infection Virus Entry inhibitor Viral disease Digestive diseases Antiviral Flaviviridae Hepacivirus Viral hepatitis C
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