Aqueous Extract of Emblica officinalis Linn (Indian gooseberry) in Combination with Iodine is More Efficacious than Iodine Alone in Mitigating Mucositis in Head and Neck Cancer Patients Undergoing Curative Radiotherapy: Retrospective Observations

• Published in: Indian journal of otolaryngology, and head, and neck surgery Vol. 74; no. Suppl 3; pp. 6330 - 6338
• Main Authors: Hegde, Sanath Kumar, Rao, Suresh, Rao, Pratima, Raghu, Shamprasad Varija, Meera, Sharake, Baliga, Manjeshwar Shrinath
• Format: Journal Article
• Language: English
• Published: New Delhi Springer India 01-12-2022; Springer Nature B.V
• Subjects: Head & neck cancer; Head and Neck Surgery; Iodine; Medicine; Medicine & Public Health; Mucositis; Original; Original Article; Otorhinolaryngology; Radiation therapy; Head and neck cancer; Treatment response; Mucositis; Cell kill; Amla; Radiation
• ISSN: 2231-3796; 0973-7707
• DOI: 10.1007/s12070-021-03059-w

Mucositis is a very painful unavoidable and common side effect in head and neck cancer patients undergoing curative radiotherapy and can affect the planned treatment. In this study, attempt is made at understanding the efficacy of
Emblica officinalis
Linn (amla) when combined with providone iodine in mitigating radiation-induced mucositis, weight loss and tumor control. This was a retrospective chart based study and was carried out by extracting the data from the files of patients with cancer of head and neck who used amla in combination with iodine or iodine alone during the course of the curative radiotherapy (> 60 Gy). The data was entered in to Microsoft excel and subjected to statistical analysis using SPSS 17 software. The results indicate that when compared with iodine alone, the group where iodine and amla gargling were used was very effective in delaying mucositis, reduced incidence of intolerable mucositis (
P
 = 0.027), quantitative grade of weight loss (
P
 = 0.016), incidence of severe weight loss (
P
 = 0.03) without affecting tumor response. The results suggest that when compared with iodine alone, amla when combined with iodine was more effective in mitigating radiation mucositis and by not interfering with the tumor cell kill. As far as the authors are aware of this is the first study that shows the usefulness of combining iodine with Amla in mitigating radiation-induced mucositis.