Sex-specific nicotine sensitization and imprinting of self-administration in rats inform GWAS findings on human addiction phenotypes

Repeated nicotine exposure leads to sensitization (SST) and enhances self-administration (SA) in rodents. However, the molecular basis of nicotine SST and SA and their biological relevance to the mounting genome-wide association study (GWAS) loci of human addictive behaviors are poorly understood. C...

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Bibliographic Details
Published in:	Neuropsychopharmacology (New York, N.Y.) Vol. 46; no. 10; pp. 1746 - 1756
Main Authors:	Kozlova, Alena, Butler, 3rd, Robert R, Zhang, Siwei, Ujas, Thomas, Zhang, Hanwen, Steidl, Stephan, Sanders, Alan R, Pang, Zhiping P, Vezina, Paul, Duan, Jubao
Format:	Journal Article
Language:	English
Published:	England Nature Publishing Group 01-09-2021 Springer International Publishing
Subjects:	Addictions Addictive behaviors Animals Behavior, Addictive - genetics Drug self-administration Female Genetic crosses Genome-wide association studies Genome-Wide Association Study Genomics Humans Imprinting Inbreeding Male Myelin Nervous system Neurosciences Nicotine Nucleus accumbens Phenotype Phenotypes Rats Rats, Inbred F344 Smoking Transcription Ventral tegmentum
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