Tolbutamide reverses hypoxic pulmonary vasoconstriction in isolated rat lungs

We have investigated the effects of tolbutamide on the hypoxic vasoconstriction of isolated, perfused rat lungs. We did this because lowered ATP may link hypoxia and constriction, and tolbutamide mimics the effects of ATP in other tissues by blocking ATP-sensitive potassium (ATP-K) channels. Pulmona...

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Bibliographic Details

Published in:	Quarterly journal of experimental physiology (1981) Vol. 74; no. 6; p. 959
Main Authors:	Robertson, B E, Paterson, D J, Peers, C, Nye, P C
Format:	Journal Article
Language:	English
Published:	England 12-11-1989
Subjects:	Adenosine Triphosphate - pharmacology Animals Hypoxia - physiopathology Lung - blood supply Male Potassium Channels - drug effects Potassium Channels - physiology Rats Rats, Inbred Strains Tolbutamide - pharmacology Vasoconstriction - drug effects
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