Disposition of ON 01210.Na (Ex-RAD(R)), a novel radioprotectant, in the isolated perfused rat liver: probing metabolic inhibition to increase systemic exposure

ON 01210.Na (Ex-RAD) is a novel benzyl styryl sulfone analog, developed as a radioprotectant by Onconova Therapeutics Inc. The objectives of this research were to evaluate the hepatobiliary disposition of ON 01210.Na in the isolated perfused rat liver (IPRL) and to determine the effect of coadminist...

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Bibliographic Details

Published in:	Journal of pharmaceutical sciences Vol. 102; no. 2; p. 732
Main Authors:	Tamhane, Mitalee, Maniar, Manoj, Ren, Chen, Benzeroual, Kenza E, Taft, David R
Format:	Journal Article
Language:	English
Published:	United States 01-02-2013
Subjects:	Animals Liver - drug effects Liver - metabolism Male Perfusion - methods Protein Binding - physiology Radiation-Protective Agents - metabolism Radiation-Protective Agents - pharmacology Rats Rats, Sprague-Dawley Sulfonamides - metabolism Sulfonamides - pharmacology
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