Lactococcus lactis JCM5805 activates anti-viral immunity and reduces symptoms of common cold and influenza in healthy adults in a randomized controlled trial

•This study was a randomized, double-blind controlled trial in 396 healthy subjects.•Heat-killed JCM5805 mitigated the incidence of common cold and influenza symptoms.•Heat-killed JCM5805 upregulated the expression levels of anti-viral genes.•Heat-killed JCM5805 upregulated the cell surface expressi...

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Bibliographic Details
Published in:	Journal of functional foods Vol. 24; pp. 492 - 500
Main Authors:	Shibata, Takeo, Kanayama, Masaya, Haida, Munetaka, Fujimoto, Shuhei, Oroguchi, Takashige, Sata, Kenji, Mita, Nobutaka, Kutsuzawa, Tomoko, Ikeuchi, Mayumi, Kondo, Mayu, Naito, Kimitoshi, Tsuda, Michio, Nishizaki, Yasuhiro, Ishii, Naoaki
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-06-2016 Elsevier
Subjects:	Lactococcus lactis JCM5805 Plasmacytoid dendritic cells (pDCs) Randomized controlled double blind trial Viperin PP Lactococcus lactis JCM5805 JCM5805 LAB PBMC pDC IFN Plasmacytoid dendritic cells (pDCs) Viperin Randomized controlled double blind trial TLR HLA ISG NK
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