Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics
After a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward with an intervention study. We had screened 1021 relatives, of which 30 had shown ICA ≥ 20 JDF units (2.9%). Among the 26/30 who participated i...
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| Published in: | Diabetes research and clinical practice Vol. 71; no. 3; pp. 320 - 333 |
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| Main Authors: | , , , , , , , , , , , , , |
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| Language: | English |
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| Abstract | After a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward with an intervention study.
We had screened 1021 relatives, of which 30 had shown ICA
≥
20
JDF units (2.9%). Among the 26/30 who participated in the intervention study, the baseline screening showed normal glucose tolerance in all, and the first-phase insulin response (FPIR) was normal in 24/26 individuals, which were randomized into Nicotinamide (
n
=
12; oral Nicotinamide, 1200
mg
m
−2
day
−1) and Placebo (
n
=
12) groups. The FPIRs and ICAs were monitored yearly. Compliance was monitored by urine Nicotinamide.
The 1.5, 3.0 and 5-year life-table estimates of keeping the FPIR
≥
10th centile were, for Nicotinamide group 100% in all time points, and for Placebo these were 90.0% (c.i.
=
100–71.4), 72.0% (c.i.
=
100–37.1) and 0.0% (c.i.
=
0.0–0.0) (
p
=
0.0091). The 5-year life-table estimates of remaining diabetes-free were 100% for Nicotinamide and 62.5% for Placebo (
p
=
0.0483). No adverse effects were observed.
Oral Nicotinamide protected beta-cell function and prevented clinical disease in ICA-positive first-degree relatives of type-1 diabetes. |
|---|---|
| AbstractList | BACKGROUNDAfter a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward with an intervention study.METHODSWe had screened 1021 relatives, of which 30 had shown ICA > or = 20 JDF units (2.9%). Among the 26/30 who participated in the intervention study, the baseline screening showed normal glucose tolerance in all, and the first-phase insulin response (FPIR) was normal in 24/26 individuals, which were randomized into Nicotinamide (n = 12; oral Nicotinamide, 1200 mg m(-2) day(-1)) and Placebo (n = 12) groups. The FPIRs and ICAs were monitored yearly. Compliance was monitored by urine Nicotinamide.RESULTSThe 1.5, 3.0 and 5-year life-table estimates of keeping the FPIR > or = 10th centile were, for Nicotinamide group 100% in all time points, and for Placebo these were 90.0% (c.i. = 100-71.4), 72.0% (c.i. = 100-37.1) and 0.0% (c.i. = 0.0-0.0) (p = 0.0091). The 5-year life-table estimates of remaining diabetes-free were 100% for Nicotinamide and 62.5% for Placebo (p = 0.0483). No adverse effects were observed.CONCLUSIONSOral Nicotinamide protected beta-cell function and prevented clinical disease in ICA-positive first-degree relatives of type-1 diabetes. After a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward with an intervention study. We had screened 1021 relatives, of which 30 had shown ICA ≥ 20 JDF units (2.9%). Among the 26/30 who participated in the intervention study, the baseline screening showed normal glucose tolerance in all, and the first-phase insulin response (FPIR) was normal in 24/26 individuals, which were randomized into Nicotinamide ( n = 12; oral Nicotinamide, 1200 mg m −2 day −1) and Placebo ( n = 12) groups. The FPIRs and ICAs were monitored yearly. Compliance was monitored by urine Nicotinamide. The 1.5, 3.0 and 5-year life-table estimates of keeping the FPIR ≥ 10th centile were, for Nicotinamide group 100% in all time points, and for Placebo these were 90.0% (c.i. = 100–71.4), 72.0% (c.i. = 100–37.1) and 0.0% (c.i. = 0.0–0.0) ( p = 0.0091). The 5-year life-table estimates of remaining diabetes-free were 100% for Nicotinamide and 62.5% for Placebo ( p = 0.0483). No adverse effects were observed. Oral Nicotinamide protected beta-cell function and prevented clinical disease in ICA-positive first-degree relatives of type-1 diabetes. After a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward with an intervention study. We had screened 1021 relatives, of which 30 had shown ICA > or = 20 JDF units (2.9%). Among the 26/30 who participated in the intervention study, the baseline screening showed normal glucose tolerance in all, and the first-phase insulin response (FPIR) was normal in 24/26 individuals, which were randomized into Nicotinamide (n = 12; oral Nicotinamide, 1200 mg m(-2) day(-1)) and Placebo (n = 12) groups. The FPIRs and ICAs were monitored yearly. Compliance was monitored by urine Nicotinamide. The 1.5, 3.0 and 5-year life-table estimates of keeping the FPIR > or = 10th centile were, for Nicotinamide group 100% in all time points, and for Placebo these were 90.0% (c.i. = 100-71.4), 72.0% (c.i. = 100-37.1) and 0.0% (c.i. = 0.0-0.0) (p = 0.0091). The 5-year life-table estimates of remaining diabetes-free were 100% for Nicotinamide and 62.5% for Placebo (p = 0.0483). No adverse effects were observed. Oral Nicotinamide protected beta-cell function and prevented clinical disease in ICA-positive first-degree relatives of type-1 diabetes. |
| Author | Acosta, Ana M. De Valdés, Marcelo Díaz Muñiz, Osvaldo P. Maiz, Alberto Foncea, Rocío Olmos, Pablo R. Hodgson, María I. Oyarzún, Cristóbal A. Claro, Juan C. Velasco, Soledad Toro, Luis A. Emmerich, Matías V. Bastías, María J. Manrique, Mónica |
| Author_xml | – sequence: 1 givenname: Pablo R. surname: Olmos fullname: Olmos, Pablo R. email: polmos@med.puc.cl organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 2 givenname: María I. surname: Hodgson fullname: Hodgson, María I. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 3 givenname: Alberto surname: Maiz fullname: Maiz, Alberto organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 4 givenname: Mónica surname: Manrique fullname: Manrique, Mónica organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 5 givenname: Marcelo Díaz surname: De Valdés fullname: De Valdés, Marcelo Díaz organization: Hospital del Profesor, Santiago, Chile – sequence: 6 givenname: Rocío surname: Foncea fullname: Foncea, Rocío organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 7 givenname: Ana M. surname: Acosta fullname: Acosta, Ana M. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 8 givenname: Matías V. surname: Emmerich fullname: Emmerich, Matías V. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 9 givenname: Soledad surname: Velasco fullname: Velasco, Soledad organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 10 givenname: Osvaldo P. surname: Muñiz fullname: Muñiz, Osvaldo P. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 11 givenname: Cristóbal A. surname: Oyarzún fullname: Oyarzún, Cristóbal A. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 12 givenname: Juan C. surname: Claro fullname: Claro, Juan C. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 13 givenname: María J. surname: Bastías fullname: Bastías, María J. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile – sequence: 14 givenname: Luis A. surname: Toro fullname: Toro, Luis A. organization: Department of Nutrition, Diabetes & Metabolism, College of Medicine, Pontificia Universidad Católica de Chile, Alameda 340, Santiago, Chile |
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| Snippet | After a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on forward... BACKGROUNDAfter a study of ICA prevalence among relatives of Type-1 diabetics (DM1) in Santiago, Chile, parents of those who tested positive asked us to go on... |
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| SubjectTerms | Adolescent Adult Autoantibodies - blood Child Child, Preschool Chile Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - immunology Diabetes Mellitus, Type 1 - prevention & control Diabetic Ketoacidosis Family Female Glucose Tolerance Test Humans Insulin - blood Insulin - metabolism Insulin Secretion Male Niacinamide - therapeutic use Nicotinamide Patient Selection Placebos Prevention Type-1 diabetes mellitus |
| Title | Nicotinamide protected first-phase insulin response (FPIR) and prevented clinical disease in first-degree relatives of type-1 diabetics |
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