Persistent Increase in Serum 25-Hydroxyvitamin D Concentration in a Dog Following Cholecalciferol Intoxication

• Published in: Frontiers in veterinary science Vol. 6; p. 472
• Main Authors: Gerhard, Charlotte, Jaffey, Jared A
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 09-01-2020
• Subjects: 25(OH)D; 25-hydroxyvitamin D; hypercalcemia; rodenticide; Veterinary Science; vitamin D; hypercalcemia; 25(OH)D; rodenticide; 25-hydroxyvitamin D; vitamin D
• ISSN: 2297-1769; 2297-1769
• DOI: 10.3389/fvets.2019.00472

Cholecalciferol is becoming an increasingly utilized rodenticide in the United States due to changes implemented by the Environmental Protection Agency (EPA) to reduce unintended exposure of wildlife to second-generation anticoagulant rodenticides. The lipophilic properties of cholecalciferol and prolonged tissue elimination are well-documented; however, long-term clinical ramifications are unknown. This report describes unique clinicopathologic and treatment features during the acute phase of cholecalciferol rodenticide toxicosis in a 4-year-old neutered Shih-Tzu mix that presented for intermittent vomiting, anorexia, polyuria, and polydipsia. In addition, this report also highlights the potential benefit of serial measurements of serum 25-hydroxyvitamin D concentrations and long-term treatment in the chronic phase of cholecalciferol rodenticide toxicosis in dogs.