Amides as modifiable directing groups in electrophilic borylation

Amide directed C-H borylation using ≥two equiv. of BBr 3 forms borenium cations containing a R 2 N(R′)C&z.dbd;O→B(Ar)Br unit which has significant Lewis acidity at the carbonyl carbon. This enables reduction of the amide unit to an amine using hydrosilanes. This approach can be applied sequentia...

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Bibliographic Details

Published in:	Chemical science (Cambridge) Vol. 14; no. 14; pp. 3865 - 3872
Main Authors:	Iqbal, Saqib A, Uzelac, Marina, Nawaz, Ismat, Wang, Zhongxing, Jones, T. Harri, Yuan, Kang, Millet, Clement R. P, Nichol, Gary S, Chotana, Ghayoor Abbas, Ingleson, Michael J
Format:	Journal Article
Language:	English
Published:	England Royal Society of Chemistry 05-04-2023 The Royal Society of Chemistry
Subjects:	Amides Aromatic compounds Boron Carbazoles Carbonyls Cations Chemistry Nitrogen Polycyclic aromatic hydrocarbons Substrates
Online Access:	Get full text
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