Directed evolution of the dioxygenase complex for the synthesis of furanone flavor compounds

Herein we report a new preparation of 4-hydroxy-2,5-dimethyl-2,3-dihydrofuran-3-one, the flavor compound strawberry furanone, based on a ‘green’ approach with a minimum number of steps. The first step is an enzymatic dioxygenation of p-xylene to form cyclohexadiene- cis-diol, followed by ring openin...

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Bibliographic Details

Published in:	Tetrahedron Vol. 60; no. 3; pp. 729 - 734
Main Authors:	Newman, Lisa M., Garcia, Henry, Hudlicky, Tomas, Selifonov, Sergey A.
Format:	Journal Article
Language:	English
Published:	Elsevier Ltd 01-01-2004
Subjects:	Fragaria
Online Access:	Get full text
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