PKPD Modeling of the Inoculum Effect of Acinetobacter baumannii on Polymyxin B in vivo

The reduction in antimicrobial activity at high bacterial counts is a microbiological phenomenon known as the inoculum effect (IE). In a previous study, a significant IE was observed for polymyxin B (PMB) against a clinical isolate of , and well described by a new pharmacokinetic-pharmacodynamic mod...

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Bibliographic Details

Published in:	Frontiers in pharmacology Vol. 13; p. 842921
Main Authors:	Chauzy, Alexia, Akrong, Grace, Aranzana-Climent, Vincent, Moreau, Jérémy, Prouvensier, Laure, Mirfendereski, Hélène, Buyck, Julien M, Couet, William, Marchand, Sandrine
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers 16-03-2022 Frontiers Media S.A
Subjects:	Acinetobacter baumannii in vivo inoculum effect Life Sciences modelling Pharmaceutical sciences Pharmacology PKPD polymyxin B (PMB) Acinetobacter baumannii PKPD in vivo polymyxin B (PMB) inoculum effect modelling
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