Unusual Imaging Findings in Brain and Spinal Cord in Two Siblings With Maple Syrup Urine Disease

ABSTRACT Maple syrup urine disease (MSUD) is a rare metabolic disease affecting the neural tissue. While the brain abnormalities present on MRI are well known, spinal imaging features have not been studied. We herewith report an unusual finding of enlarged Virchow Robin spaces in brain and novel spi...

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Bibliographic Details
Published in:	Journal of neuroimaging Vol. 23; no. 4; pp. 540 - 542
Main Authors:	Bhat, Maya, Prasad, Chandrajit, Bindu, Parayil Sankaran, Aziz, Zarina, Christopher, Rita, Saini, Jitender
Format:	Journal Article
Language:	English
Published:	United States Wiley Subscription Services, Inc 01-10-2013
Subjects:	brain Brain - pathology Child Child, Preschool Diagnosis, Differential Female Humans Magnetic Resonance Imaging - methods Male Maple Syrup Urine Disease - pathology Metabolic disorders MRI MSUD Neuroimaging Siblings Spinal cord Spinal Cord - pathology MSUD spinal cord brain MRI
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Summary:	ABSTRACT Maple syrup urine disease (MSUD) is a rare metabolic disease affecting the neural tissue. While the brain abnormalities present on MRI are well known, spinal imaging features have not been studied. We herewith report an unusual finding of enlarged Virchow Robin spaces in brain and novel spinal cord changes in two biochemically diagnosed cases of MSUD. To the best of our knowledge, spinal MRI findings in cases of MSUD have not been previously reported. Knowledge of spinal MRI findings may be useful in diagnosis of this rare disorder.
Bibliography:	None Conflict of Interest ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1051-2284 1552-6569
DOI:	10.1111/j.1552-6569.2012.00746.x