Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: A microdialysis study

Animal studies have documented a critical role for cytokines in cell signaling events underlying inflammation and pain associated with tissue injury. While clinical reports indicate an important role of cytokines in inflammatory pain, methodological limitations have made systematic human studies dif...

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Bibliographic Details
Published in:	Pain (Amsterdam) Vol. 139; no. 1; pp. 15 - 27
Main Authors:	Angst, M.S., Clark, J.D., Carvalho, B., Tingle, M., Schmelz, M., Yeomans, D.C.
Format:	Journal Article
Language:	English
Published:	Amsterdam Elsevier B.V 30-09-2008 Lippincott Williams & Wilkins, Inc Elsevier
Subjects:	Adult Analgesia Anti-hyperalgesia Anti-inflammatory Biological and medical sciences Biomarkers - metabolism Chemokines Cross-Over Studies Cyclooxygenase Inhibitor Cyclooxygenase Inhibitors - administration & dosage Cytokines Cytokines - antagonists & inhibitors Cytokines - biosynthesis Cytokines - metabolism Double-Blind Method Female Fundamental and applied biological sciences. Psychology Heat Hot Temperature - adverse effects Human Humans Hyperalgesia Ibuprofen Inflammation Inflammation Mediators - physiology Interleukins Male Mechanical Medical sciences Microdialysis Microdialysis - methods Nerve Growth Factor Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Pain Measurement - drug effects Pain Measurement - methods Skin Skin - chemistry Skin - drug effects Skin - metabolism Somesthesis and somesthetic pathways (proprioception, exteroception, nociception); interoception; electrolocation. Sensory receptors Sunburn Sunburn - drug therapy Sunburn - metabolism Ultraviolet B Vertebrates: nervous system and sense organs Human Cytokines Cyclooxygenase Inhibitor Anti-hyperalgesia Inflammation Nerve Growth Factor Hyperalgesia Analgesia Heat Microdialysis Sunburn Interleukins Ultraviolet B Ibuprofen Mechanical Skin Anti-inflammatory Chemokines Growth Interleukin 6 Signal transduction Pain Release Cytokine Pharmacology Technique
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