EGFR, KRAS, BRAF, and HER‐2 molecular status in brain metastases from 77 NSCLC patients

The aim of this study was to determine the frequency of EGFR, KRAS, BRAF, and HER‐2 mutations in brain metastases from non‐small cell lung carcinomas (BM‐NSCLC). A total of 77 samples of BM‐NSCLC were included and 19 samples of BM from breast, kidney, and colorectal tumors were also studied as contr...

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Bibliographic Details
Published in:	Cancer medicine (Malden, MA) Vol. 2; no. 3; pp. 296 - 304
Main Authors:	Villalva, Claire, Duranton‐Tanneur, Valérie, Guilloteau, Karline, Burel‐Vandenbos, Fanny, Wager, Michel, Doyen, Jérôme, Levillain, Pierre Marie, Fontaine, Denys, Blons, Hélène, Pedeutour, Florence, Karayan‐Tapon, Lucie
Format:	Journal Article
Language:	English
Published:	United States John Wiley & Sons, Inc 01-06-2013 Blackwell Publishing Ltd
Subjects:	Adult Aged Aged, 80 and over Amino acids BRAF Brain cancer brain metastases Brain Neoplasms - genetics Brain Neoplasms - secondary Breast Cancer Biology Cancer therapies Carcinoma, Non-Small-Cell Lung - genetics Carcinoma, Non-Small-Cell Lung - pathology Deoxyribonucleic acid DNA Epidermal growth factor epidermal growth factor receptor Epidermal growth factor receptors Female Genes, ras Genetic analysis HER‐2 Humans Kidneys Kinases KRAS Lung cancer Lung carcinoma Lung Neoplasms - genetics Lung Neoplasms - pathology Male Medical prognosis Melanoma Metastases Metastasis Middle Aged Mutation Non-small cell lung carcinoma non‐small cell lung cancer Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Receptor, Epidermal Growth Factor - genetics Receptor, ErbB-2 - genetics Small cell lung carcinoma Software Tumors France non-small cell lung cancer BRAF KRAS HER-2 brain metastases epidermal growth factor receptor
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