Granulocyte Colony Stimulating Factor (G-CSF) can allow treatment with clozapine in a patient with severe Benign Ethnic Neutropaenia (BEN): a case report

Clozapine is the treatment of choice for treatment-resistant schizophrenia, but it is associated with a risk of neutropaenia and agranulocytosis. Clozapine use is regulated by mandatory blood monitoring in the UK, requiring cessation of treatment should the absolute neutrophil count (ANC) drop below...

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Bibliographic Details
Published in:	Journal of psychopharmacology (Oxford) Vol. 26; no. 9; pp. 1280 - 1282
Main Authors:	Spencer, Benjamin WJ, Williams, Hugh RJ, Gee, Siobhan H, Whiskey, Eromona, Rodrigues, Joseph P, Mijovic, Aleksandar, MacCabe, James H
Format:	Journal Article
Language:	English
Published:	London, England SAGE Publications 01-09-2012 Sage Publications Sage Publications Ltd
Subjects:	Adult Adult and adolescent clinical studies African Continental Ancestry Group Antipsychotic Agents - adverse effects Antipsychotic Agents - therapeutic use Benign Biological and medical sciences Blood Case reports Clozapine Clozapine - adverse effects Clozapine - therapeutic use Colonies Drug Interactions Drug Monitoring Drug Resistance Filgrastim Granulocyte colony-stimulating factor Granulocyte Colony-Stimulating Factor - adverse effects Granulocyte Colony-Stimulating Factor - therapeutic use Humans Immunologic Factors - adverse effects Immunologic Factors - therapeutic use Leukocyte Count Leukocytes (granulocytic) Leukocytes (neutrophilic) Male Medical sciences Mental disorders Mental health care Neuropharmacology Neutropenia Neutropenia - chemically induced Neutropenia - drug therapy Neutropenia - ethnology Neutropenia - physiopathology Neutrophils - drug effects Neutrophils - immunology Pharmacology. Drug treatments Polyethylene Glycols Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychopharmacology Psychoses Recombinant Proteins - adverse effects Recombinant Proteins - therapeutic use Risk assessment Schizophrenia Schizophrenia - blood Schizophrenia - drug therapy Schizophrenia - immunology Severity of Illness Index Treatment Outcome United Kingdom Young Adult United Kingdom > UK clozapine BEN schizophrenia G-CSF Human Dibenzodiazepine derivatives Atypical antipsychotic Neuroleptic Psychotropic Cytokine Schizophrenia Clozapine Ethnic group Psychosis Case study Granulocyte colony stimulating factor D2 Dopamine receptor Treatment Antagonist
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