An unexpected protective role of low-affinity allergen-specific IgG through the inhibitory receptor FcγRIIb

Induction of allergen-specific IgG antibodies is a critical parameter for successful allergen-specific immunotherapy. IgG antibodies can inhibit IgE-mediated mast cell activation through direct allergen neutralization or through the inhibitory receptor FcγRIIb. The affinity of IgE antibodies to the...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 142; no. 5; pp. 1529 - 1536.e6
Main Authors:	Zha, Lisha, Leoratti, Fabiana M.S., He, Lichun, Mohsen, Mona O., Cragg, Mark, Storni, Federico, Vogel, Monique, Bachmann, Martin F.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-11-2018 Elsevier Limited
Subjects:	Activation Affinity Allergens Allergens - immunology Allergies Allergy Animals Antibodies, Monoclonal - immunology Cell activation Competition Cross-reactivity Desensitization, Immunologic FcγRIIb-mediated inhibition Fel d 1 Female Glycoproteins - immunology Hypotheses Immunoglobulin E Immunoglobulin G Immunoglobulin G - immunology Immunoglobulins Immunotherapy Inhibition Light low-affinity antibodies Mast Cells - immunology Mice, Inbred BALB C Mutation Neutralization Plasmids Receptors, IgG - immunology Signal transduction vaccination Allergy FcγRIIb-mediated inhibition RU DARPin low-affinity antibodies Fel d 1 FACS BMMC vaccination SIT
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