Photochemically treated fresh frozen plasma for transfusion of patients with acquired coagulopathy of liver disease

An ex vivo photochemical treatment (PCT) process was developed to inactivate pathogens in fresh frozen plasma (PCT-FFP). A prospective, controlled, double-blinded, randomized study was conducted to evaluate the efficacy and safety of PCT-FFP compared with conventional FFP (C-FFP). Patients (n = 121)...

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Bibliographic Details
Published in:	Blood Vol. 107; no. 9; pp. 3753 - 3760
Main Authors:	Mintz, Paul D., Bass, Nathan M., Petz, Lawrence D., Steadman, Randolph, Streiff, Michael, McCullough, Jeffery, Burks, Sandra, Wages, David, Van Doren, Sally, Corash, Laurence
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 01-05-2006 The Americain Society of Hematology
Subjects:	Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Biological and medical sciences Blood Coagulation Disorders - blood Blood Coagulation Disorders - therapy Blood Transfusion Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis Double-Blind Method Factor VII - metabolism Female Hematologic and hematopoietic diseases Hemostasis Humans Liver Diseases - blood Liver Diseases - therapy Liver Transplantation Male Medical sciences Middle Aged Partial Thromboplastin Time Photopheresis Plasma Platelet diseases and coagulopathies Prospective Studies Prothrombin Time Safety Transfusions. Complications. Transfusion reactions. Cell and gene therapy Human Amotosalen Transfusion Acquired Photochemical method Hepatic disease Hemopathy Inactivation Blood plasma Infection Prevention Treatment Pathogenic Digestive diseases Transmission from man to man Coagulation factor Coagulopathy
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