Efficacy of chloroquine, sulfadoxine–pyrimethamine and amodiaquine for treatment of uncomplicated Plasmodium falciparum malaria among children under five in Bongor and Koumra, Chad

We report two 28-day in-vivo antimalarial efficacy studies carried out in the urban centres of Bongor and Koumra, southern Chad. We assess chloroquine (CQ), sulfadoxine–pyrimethamine (SP) and amodiaquine (AQ) to treat Plasmodium falciparum uncomplicated malaria. Methods and outcome classification co...

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Published in:	Transactions of the Royal Society of Tropical Medicine and Hygiene Vol. 100; no. 5; pp. 419 - 426
Main Authors:	Grandesso, Francesco, Bachy, Catherine, Donam, Issa, Ntambi, John, Habimana, Joseph, D’Alessandro, Umberto, Maikere, Jacob, Vanlerberghe, Veerle, Kerah, Clément Hinzoumbe, Guthmann, Jean-Paul
Format:	Journal Article
Language:	English
Published:	Oxford Elsevier Ltd 01-05-2006 Royal Society of Tropical Medicine and Hygiene Elsevier
Subjects:	Amodiaquine Amodiaquine - therapeutic use Animals Biological and medical sciences Chad Child, Preschool Chloroquine Chloroquine - therapeutic use Drug Combinations Drug Resistance Drug Therapy, Combination Genes, Protozoan Genotype Human protozoal diseases Humans Infant Infectious diseases Malaria Malaria, Falciparum - drug therapy Medical sciences Parasitic diseases Parasitic Sensitivity Tests Plasmodium falciparum Plasmodium falciparum - genetics Prospective Studies Protozoal diseases Pyrimethamine - therapeutic use Resistance Sulfadoxine - therapeutic use Sulfadoxine–pyrimethamine Treatment Outcome Urban Population Chad Africa Resistance Plasmodium falciparum Malaria Chloroquine Amodiaquine Chad Sulfadoxine–pyrimethamine Sulfanilamide derivatives Antimalarial Protozoal disease Amine Tropical medicine Antiinfectious Sulfadoxine Antirheumatic agent Child Human Protozoa Apicomplexa Drug combination Pyrimethamine Quinoline derivatives Parasitosis Infection Chemotherapy Treatment Parasiticide Sulfadoxine- pyrimethamine Antibacterial agent
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