Phenotypic Analysis of Hairy Cell Leukemia: “Variant” Cases Express the Interleukin-2 Receptor β Chain, But Not the α Chain (CD25)

Hairy cell leukemia (HCL) is a B-cell chronic lymphoproliferative disorder in which the pathologic cells show a strong expression of CD25 (interleukin-2 [IL-2] receptor α chain or p55). “Variant” cases of HCL, characterized by hyperleukocytosis, neoplastic elements with a prominent nucleolus and a h...

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Bibliographic Details
Published in:	Blood Vol. 82; no. 2; pp. 528 - 535
Main Authors:	de Totero, Daniela, Tazzari, Pier Luigi, Lauria, Francesco, Raspadori, Donatella, di Celle, Paola Francia, Carbone, Anna, Gobbi, Marco, Foa, Robert
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 15-07-1993 The Americain Society of Hematology
Subjects:	Adult Aged Antibodies, Monoclonal B-Lymphocytes - immunology B-Lymphocytes - pathology Base Sequence Biological and medical sciences Cell Membrane - immunology Female Fluorescent Antibody Technique Hematologic and hematopoietic diseases Humans Leukemia, Hairy Cell - immunology Leukemia, Hairy Cell - pathology Leukemia, Lymphocytic, Chronic, B-Cell - immunology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Middle Aged Molecular Sequence Data Phenotype Receptors, Interleukin-2 - analysis Receptors, Interleukin-2 - chemistry Receptors, Interleukin-2 - genetics RNA, Messenger - analysis Human Hairy cell leukemia Phenotype Membrane receptor Interleukin 2 Beta-Peptide chain Exploration Malignant hemopathy Gene expression
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