An update on immunologic mechanisms in the respiratory mucosa in response to air pollutants

Every day, we breathe in more than 10,000 L of air that contains a variety of air pollutants that can pose negative consequences to lung health. The respiratory mucosa formed by the airway epithelium is the first point of contact for air pollution in the lung, functioning as a mechanical and immunol...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 143; no. 6; pp. 1989 - 2001
Main Authors:	Huff, Ryan D., Carlsten, Chris, Hirota, Jeremy A.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01-06-2019 Elsevier Limited
Subjects:	Air pollution Airway epithelial cells Antimicrobial agents Antioxidants Bacteria Biomass Cell adhesion & migration Chronic obstructive pulmonary disease Coal Cytochrome Cytokines Epigenetics Epithelial cells Epithelium gene-pollution interactions Genetic diversity Genetic variance host defense peptides Humidity Immune response Inflammation Kinases Lungs Metabolism Mucosal immunity Mucus Neutrophils Oxidative stress Pathogens Pattern recognition receptors Peptides Phenotypes Pollutants Pollution Proteins Respiratory tract Tight junctions NADPH TSLP antioxidants gene-pollution interactions SOD Airway epithelial cells AhR ICAM-1 SRM NO2 NAC NF-κB host defense peptides Nrf2 PAH RNS ROS NIST GSH oxidative stress COPD
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