Molecular Monitoring of the myl/Retinoic Acid Receptor-α Fusion Gene in Acute Promyelocytic Leukemia by Polymerase Chain Reaction

The acute promyelocytic leukemia (APL) t(15;17) translocation generates a myl/retinoic acid receptor-alpha (RAR-alpha) chimeric gene that is transcribed as a fusion myl/RAR-alpha messenger RNA. Using primer sets derived from RAR-alpha and myl cDNAs, we were able to amplify the breakpoint sites of th...

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Bibliographic Details
Published in:	Blood Vol. 80; no. 2; pp. 492 - 497
Main Authors:	Biondi, Andrea, Rambaldi, Alessandro, Pandolfi, Pier Paolo, Rossi, Vincenzo, Giudici, Giovanni, Alcalay, Myriam, Coco, Francesco Lo, Diverio, Daniela, Pogliani, Enrico M., Lanzi, Eraldo M., Mandelli, Franco, Masera, Giuseppe, Barbui, Tiziano, Pelicci, Pier Giuseppe
Format:	Journal Article
Language:	English
Published:	Washington, DC Elsevier Inc 15-07-1992 The Americain Society of Hematology
Subjects:	Adolescent Adult Antineoplastic Combined Chemotherapy Protocols Base Sequence Biological and medical sciences Bone Marrow - pathology Bone Marrow Transplantation Carrier Proteins - genetics Child Child, Preschool Chromosome Mapping Chromosomes, Human, Pair 15 Chromosomes, Human, Pair 17 Cloning, Molecular DNA, Neoplasm - genetics Exons Female Follow-Up Studies Hematologic and hematopoietic diseases Humans Introns Leukemia, Promyelocytic, Acute - blood Leukemia, Promyelocytic, Acute - genetics Leukemia, Promyelocytic, Acute - pathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Male Medical sciences Molecular Sequence Data Oligodeoxyribonucleotides Oncogenes Polymerase Chain Reaction - methods Receptors, Retinoic Acid Translocation, Genetic Tretinoin - metabolism Chromosomal aberration Human Promyelocytic leukemia Polymerase chain reaction Abnormal chromosome Exploration Malignant hemopathy Molecular biology Retinoic acid Chromosome translocation
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