Pravastatin combination with sorafenib does not improve survival in advanced hepatocellular carcinoma

[Display omitted] •Phase III, multicenter study, comparing sorafenib + pravastin to sorafenib alone in Child-Pugh A patients with HCC.•The sorafenib-pravastatin combination did not improve overall survival in our study population.•Significant prognostic factors for overall survival were CLIP score,...

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Bibliographic Details
Published in:	Journal of hepatology Vol. 71; no. 3; pp. 516 - 522
Main Authors:	Jouve, Jean-Louis, Lecomte, Thierry, Bouché, Olivier, Barbier, Emilie, Khemissa Akouz, Faiza, Riachi, Ghassan, Nguyen Khac, Eric, Ollivier-Hourmand, Isabelle, Debette-Gratien, Maryline, Faroux, Roger, Villing, Anne-Laure, Vergniol, Julien, Ramee, Jean-François, Bronowicki, Jean-Pierre, Seitz, Jean-François, Legoux, Jean-Louis, Denis, Jacques, Manfredi, Sylvain, Phelip, Jean-Marc
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-09-2019 Elsevier Science Ltd
Subjects:	Adult Aged Aged, 80 and over Antineoplastic Agents - adverse effects Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Antineoplastic Combined Chemotherapy Protocols - therapeutic use Carcinoma, Hepatocellular - drug therapy Carcinoma, Hepatocellular - mortality Diarrhea Diarrhea - chemically induced Female Follow-Up Studies HCC Hepatocellular carcinoma Humans Kaplan-Meier Estimate Liver cancer Liver Neoplasms - drug therapy Liver Neoplasms - mortality Male Medical prognosis Middle Aged Multivariate analysis Nausea Patients Population studies Pravastatin Pravastatin - adverse effects Pravastatin - therapeutic use Prognosis Progression-Free Survival Quality of Life RCT Sorafenib - adverse effects Sorafenib - therapeutic use Statins Survival Systemic therapy Toxicity Tyrosine kinase inhibitors Vomiting Systemic therapy Liver cancer HCC RCT Tyrosine kinase inhibitors Statins
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