Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility

Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is...

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Published in:	Molecular and cellular endocrinology Vol. 273; no. 1; pp. 25 - 31
Main Authors:	Esposito, G., Vitale, A.M., Leijten, F.P.J., Strik, A.M., Koonen-Reemst, A.M.C.B., Yurttas, P., Robben, T.J.A.A., Coonrod, S., Gossen, J.A.
Format:	Journal Article
Language:	English
Published:	Ireland Elsevier Ireland Ltd 15-07-2007 Elsevier
Subjects:	Actin Cytoskeleton - metabolism Animals Citrulline - metabolism Cytoskeletal sheet Cytoskeleton - enzymology Cytoskeleton - metabolism Cytoskeleton - ultrastructure Embryo, Mammalian - cytology Estrous Cycle - physiology Female Fertility Fertility - physiology Gene Targeting Hydrolases - deficiency Hydrolases - metabolism Knockout Mice Microtubules - metabolism Oocyte Oocytes - cytology Oocytes - enzymology Oocytes - ultrastructure Ovary - cytology Ovary - growth & development PAD6 Protein-Arginine Deiminases Skin - cytology Cytoskeletal sheet Fertility PAD6 Oocyte Knockout Life Sciences
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Abstract	Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected. The absence of the PAD6 protein and consequently absence of citrullination activity in oocytes results in dispersal of the cytoskeletal sheets in oocytes, indicating an essential role of these germ cell-specific structures in zygote/embryo development. PAD6 deficient mice do not show any other overt phenotype. Thus, we identify citrullination as a new regulator of fertility.
AbstractList	Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected. The absence of the PAD6 protein and consequently absence of citrullination activity in oocytes results in dispersal of the cytoskeletal sheets in oocytes, indicating an essential role of these germ cell-specific structures in zygote/embryo development. PAD6 deficient mice do not show any other overt phenotype. Thus, we identify citrullination as a new regulator of fertility. Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we generated mice deficient for PAD6. Here we show that inactivation of the PAD6 gene in mice leads to female infertility whereas male fertility is not affected. The absence of the PAD6 protein and consequently absence of citrullination activity in oocytes results in dispersal of the cytoskeletal sheets in oocytes, indicating an essential role of these germ cell-specific structures in zygote/embryo development. PAD6 deficient mice do not show any other overt phenotype. Thus, we identify citrullination as a new regulator of fertility.
Author	Robben, T.J.A.A. Vitale, A.M. Strik, A.M. Esposito, G. Yurttas, P. Koonen-Reemst, A.M.C.B. Coonrod, S. Gossen, J.A. Leijten, F.P.J.
Author_xml	– sequence: 1 givenname: G. surname: Esposito fullname: Esposito, G. organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands – sequence: 2 givenname: A.M. surname: Vitale fullname: Vitale, A.M. organization: Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York 10021, United States – sequence: 3 givenname: F.P.J. surname: Leijten fullname: Leijten, F.P.J. organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands – sequence: 4 givenname: A.M. surname: Strik fullname: Strik, A.M. organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands – sequence: 5 givenname: A.M.C.B. surname: Koonen-Reemst fullname: Koonen-Reemst, A.M.C.B. organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands – sequence: 6 givenname: P. surname: Yurttas fullname: Yurttas, P. organization: Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York 10021, United States – sequence: 7 givenname: T.J.A.A. surname: Robben fullname: Robben, T.J.A.A. organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands – sequence: 8 givenname: S. surname: Coonrod fullname: Coonrod, S. organization: Department of Genetic Medicine, Weill Medical College of Cornell University, 1300 York Avenue, New York 10021, United States – sequence: 9 givenname: J.A. surname: Gossen fullname: Gossen, J.A. email: jan.gossen@organon.com organization: Department of Target Discovery, NV Organon, 5340 BH Oss, The Netherlands
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Keywords	Cytoskeletal sheet Fertility PAD6 Oocyte Knockout Life Sciences
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Snippet	Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we... Peptidylarginine deiminase 6 (PAD6) is an enzyme that is uniquely expressed in male and female germ cells. To study the function of this enzyme in vivo we...
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SubjectTerms	Actin Cytoskeleton - metabolism Animals Citrulline - metabolism Cytoskeletal sheet Cytoskeleton - enzymology Cytoskeleton - metabolism Cytoskeleton - ultrastructure Embryo, Mammalian - cytology Estrous Cycle - physiology Female Fertility Fertility - physiology Gene Targeting Hydrolases - deficiency Hydrolases - metabolism Knockout Mice Microtubules - metabolism Oocyte Oocytes - cytology Oocytes - enzymology Oocytes - ultrastructure Ovary - cytology Ovary - growth & development PAD6 Protein-Arginine Deiminases Skin - cytology
Title	Peptidylarginine deiminase (PAD) 6 is essential for oocyte cytoskeletal sheet formation and female fertility
URI	https://dx.doi.org/10.1016/j.mce.2007.05.005 https://www.ncbi.nlm.nih.gov/pubmed/17587491 https://search.proquest.com/docview/70688679 https://hal.science/hal-00531927
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