A wireless handheld probe with spectrally constrained evolution strategies for diffuse optical imaging of tissue

• Published in: Review of scientific instruments Vol. 83; no. 3; p. 033108
• Main Authors: Flexman, M L, Kim, H K, Stoll, R, Khalil, M A, Fong, C J, Hielscher, A H
• Format: Journal Article
• Language: English
• Published: United States 01-03-2012
• Subjects: Image Processing, Computer-Assisted; Molecular Imaging - instrumentation; Optical Phenomena; Phantoms, Imaging; Time Factors; Wireless Technology
• ISSN: 1089-7623
• DOI: 10.1063/1.3694494

We present a low-cost, portable, wireless diffuse optical imaging device. The handheld device is fast, portable, and can be applied to a wide range of both static and dynamic imaging applications including breast cancer, functional brain imaging, and peripheral artery disease. The continuous-wave probe has four near-infrared wavelengths and uses digital detection techniques to perform measurements at 2.3 Hz. Using a multispectral evolution algorithm for chromophore reconstruction, we can measure absolute oxygenated and deoxygenated hemoglobin concentration as well as scattering in tissue. Performance of the device is demonstrated using a series of liquid phantoms comprised of Intralipid(®), ink, and dye.