Siderophore conjugates

There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins. Among the sy...

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Bibliographic Details
Published in:	Annals of the New York Academy of Sciences Vol. 1277; no. 1; pp. 115 - 126
Main Author:	Page, Malcolm G. P.
Format:	Journal Article
Language:	English
Published:	Malden, USA Blackwell Publishing Inc 01-01-2013 Wiley Subscription Services, Inc
Subjects:	Anti-Bacterial Agents - chemistry Antibiotics Bacteria Bacteriology BAL30072 Barriers beta-Lactams - chemistry Conjugates Glycopeptides Humans iron transport Membranes Nucleosides Permeability sideromycin siderophore antibiotics Siderophores - chemistry
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Summary:	There has been considerable effort expended in the investigation of the potential of siderophore conjugates of antibiotics to circumvent the permeability barrier imposed by the outer membrane of Gram‐negative bacteria. There is also a small group of natural conjugates, the sideromycins. Among the synthetic analogues that have been investigated are conjugates of nucleosides, glycopeptides, macrolides, fluroquinolones, and, above all, β‐lactams. Despite this effort, few compounds have progressed beyond experimental studies. One compound, the siderophore monosulfactam BAL30072, is in early clinical studies.
Bibliography:	istex:94815F6304D00E706C8884ED3555D6DE495B79E7 ArticleID:NYAS12024 ark:/67375/WNG-5270P1N2-W ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Feature-1
ISSN:	0077-8923 1749-6632
DOI:	10.1111/nyas.12024